布地奈德联合沙丁胺醇治疗婴幼儿毛细支气管炎的临床观察

发布时间：2019-03-31 11:12

【摘要】：目的:探讨在沙丁胺醇基础上加用布地奈德治疗婴幼儿毛细支气管炎的疗效、安全性和经济性。方法:采用前瞻性研究方法,选择2014年10月-2016年4月我院毛细支气管炎的住院患儿160例。按入院号顺序,单号为观察组,双号为对照组,各80例。两组患儿均给予常规治疗。对照组患儿给予吸入用硫酸沙丁胺醇溶液0.25 m L加入0.9%氯化钠注射液3 m L,q8 h;观察组患儿给予吸入用布地奈德混悬液2 m L+吸入用硫酸沙丁胺醇溶液0.25 m L加入0.9%氯化钠注射液1 m L,q8 h;两组患儿均采用氧气驱动雾化吸入,均连续治疗5~7 d。观察两组患儿临床症状消失时间、住院时间、临床疗效,比较治疗药品(雾化吸入药品和其他治疗药品)费用,并记录不良反应发生情况。结果:两组患儿咳嗽消失时间、喘息消失时间、Up音消失时间、三凹征消失时间和住院时间比较,差异均无统计学意义(P0.05);观察组患儿的临床总有效率(95.00%)与对照组(92.50%)比较,差异无统计学意义(P0.05);观察组患儿雾化吸入药品费用[(355.77±10.98)元]明显高于对照组[(26.83±2.86)元],差异有统计学意义(P0.05);两组患儿常规治疗药品费用比较,差异无统计学意义(P0.05);两组患儿治疗期间均未见明显不良反应发生。结论:在沙丁胺醇基础上雾化吸入布地奈德治疗婴幼儿毛细支气管炎并不能显著减轻病情、缩短住院时间和提高临床疗效,但增加了治疗费用。
[Abstract]:Objective: to investigate the efficacy, safety and economy of budesonide on the basis of salbutamol in the treatment of infantile bronchiolitis. Methods: 160 cases of bronchiolitis in our hospital from October 2014 to April 2016 were studied prospectively. According to the order of admission number, order number is observation group, double number is control group, each 80 cases. Both groups were given routine treatment. The control group was given salbutamol sulfate solution of 0.25 mL and 0.9% sodium chloride injection for 3 mL, Q8 h after inhaling salbutamol sulfate solution. The children in the observation group were given budesonide suspension (2 mL) and salbutamol sulfate solution (0.25 mL) plus 0.9% sodium chloride injection (1 mL, Q 8 h). The children in both groups were treated with oxygen-driven atomization inhalation for 5 d and 7 d continuously. The time of disappearance of clinical symptoms, the length of hospitalization, the clinical efficacy, the cost of therapeutic drugs (atomized inhaled drugs and other therapeutic drugs) were compared between the two groups, and the occurrence of adverse reactions was recorded. Results: there was no significant difference in cough disappearance time, wheezing disappearance time, uptone disappearance time, three concave sign disappearance time and hospitalization time between the two groups (P0.05). Compared with the control group (92.50%), the total clinical effective rate of the observation group (95.00%) had no significant difference (P0.05). The cost of aerosol inhalation in the observation group [(355.77 卤10.98) yuan] was significantly higher than that in the control group [(26.83 卤2.86) yuan], the difference was statistically significant (P0.05). There was no significant difference in the cost of routine drugs between the two groups (P0.05), and no significant adverse reactions were observed in the two groups. Conclusion: inhaling budesonide on the basis of salbutamol can not significantly reduce the condition of bronchiolitis, shorten the hospitalization time and improve the clinical efficacy, but increase the cost of treatment.
【作者单位】：泰州市人民医院儿科;
【分类号】：R725.6

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