自身炎症性疾病生物制剂治疗
发布时间：2019-03-31 17:17
【摘要】：自身炎症性疾病是由于调节固有免疫系统重要蛋白突变引起无法控制的炎性反应综合征的总称。对于该类疾病分子机制的深入揭示使得生物制剂的应用成为可能。白介素(IL)-1受体拮抗剂在冷炎素相关周期性综合征中的成功应用是选择性阻断单一细胞因子消除炎性反应最好的例子,并且IL-1拮抗剂目前已用于幼年特发性关节炎(JIA)、肿瘤坏死因子(TNF)受体相关周期性综合征及家族性地中海热等自身炎症性疾病。TNF抑制剂用于TNF受体相关周期性综合征的发热,亦可使家族性地中海热合并淀粉样变的患者获益。TNF-α抑制剂是Blau综合征最常用的治疗,有助于控制关节病变。IL-6受体拮抗剂用于全身型JIA,可明显缓解关节症状,其在TNF受体相关周期性综合征及家族性地中海热中的应用也有个例报道。
[Abstract]:Autoimmune disease is an uncontrollable inflammatory response syndrome caused by mutations in proteins that regulate the innate immune system. The further discovery of the molecular mechanism of this kind of disease makes the application of biological agents possible. The successful use of interleukin-1 receptor antagonist (IL)-1) in the treatment of cold-associated periodic syndrome is the best example of selective blocking of a single cytokine to eliminate inflammatory responses. And IL-1 antagonists have been used in juvenile idiopathic arthritis (JIA),). Tumor necrosis factor (TNF) receptor-associated periodic syndrome and familial Mediterranean fever. TNF inhibitors are used to treat fever in TNF receptor-associated periodic syndrome. TNF-伪 inhibitors are the most commonly used treatment for Blau syndrome and help to control joint diseases. Il-6 receptor antagonists can significantly relieve joint symptoms in patients with generalized JIA,. Its application in TNF receptor-associated periodic syndrome and familial Mediterranean fever has also been reported.
【作者单位】： 中国医学科学院北京协和医学院北京协和医院儿科;
【分类号】：R725.9
本文编号：2451114
[Abstract]:Autoimmune disease is an uncontrollable inflammatory response syndrome caused by mutations in proteins that regulate the innate immune system. The further discovery of the molecular mechanism of this kind of disease makes the application of biological agents possible. The successful use of interleukin-1 receptor antagonist (IL)-1) in the treatment of cold-associated periodic syndrome is the best example of selective blocking of a single cytokine to eliminate inflammatory responses. And IL-1 antagonists have been used in juvenile idiopathic arthritis (JIA),). Tumor necrosis factor (TNF) receptor-associated periodic syndrome and familial Mediterranean fever. TNF inhibitors are used to treat fever in TNF receptor-associated periodic syndrome. TNF-伪 inhibitors are the most commonly used treatment for Blau syndrome and help to control joint diseases. Il-6 receptor antagonists can significantly relieve joint symptoms in patients with generalized JIA,. Its application in TNF receptor-associated periodic syndrome and familial Mediterranean fever has also been reported.
【作者单位】： 中国医学科学院北京协和医学院北京协和医院儿科;
【分类号】：R725.9
【相似文献】
相关期刊论文 前9条
1 蔡宇波;张文明;曹兰芳;;生物制剂在治疗幼年特发性关节炎中的临床应用进展[J];实用儿科临床杂志;2010年09期
2 吴凤岐;;生物制剂在幼年特发性关节炎中的应用[J];实用儿科临床杂志;2012年09期
3 王经纬;;口服生物制剂可以降低极低出生体重儿坏死性小肠结肠炎的发病率和严重程度[J];世界核心医学期刊文摘(儿科学分册);2006年05期
4 臧焰;肾病患儿血单个核细胞白细胞介素1β及其受体拮抗剂的基因表达[J];中华医学信息导报;1995年04期
5 刘学辉，杨霁云，，王申五;肾病患儿外周血单个核细胞中白细胞介素1β及其受体拮抗剂的基因表达[J];中华医学杂志;1995年03期
6 林娜;刘运广;莫锦丽;陈霞静;覃志坚;李强;;白细胞介素-1受体拮抗剂对多柔比星肾病大鼠的治疗作用[J];实用儿科临床杂志;2009年05期
7 李卓颖;杨作成;;生物制剂治疗川崎病的进展[J];临床儿科杂志;2014年06期
8 王丽杰;刘春英;许玲芬;高红;姜卫国;孙梅;;血小板活化因子受体拮抗剂对幼年大鼠肠黏膜上皮细胞间紧密连接蛋白的影响[J];世界华人消化杂志;2006年04期
9 吴小川;彭晓杰;张国珍;;幼年特发性关节炎治疗进展[J];实用儿科临床杂志;2007年09期
相关博士学位论文 前1条
1 刘春英;内毒素血症幼年大鼠胃黏膜细胞保护作用及PAF受体拮抗剂干预的研究[D];中国医科大学;2006年
本文编号：2451114
本文链接：https://www.wllwen.com/yixuelunwen/eklw/2451114.html
最近更新
教材专著
