辅助生育技术胎儿心脏形态及功能改变研究

发布时间：2018-05-21 04:32

本文选题：辅助生育技术 + 自然受孕　；参考：《中国超声医学杂志》2015年03期

【摘要】：目的本研究通过对辅助生育技术(ART)受孕胎儿与自然受孕胎儿的心脏形态、功能进行对比,探究ART受孕胎儿是否存在心脏形态及功能改变。方法于我院行胎儿超声心动图检查的孕龄与孕周匹配的ART孕妇与自然受孕孕妇各35例,记录两组病例心脏形态及心脏功能指标。结果 ART组胎儿表现出了心血管系统重塑,包括左、右房面积增大,左、右室呈球形并球形指数减低,左室游离壁、室间隔、右室游离壁厚度增加,主动脉、肺动脉增宽,左室FS减低,左室Tei指数增加,二尖瓣、三尖瓣瓣环位移减低,二尖瓣、三尖瓣E峰减速时间降低。结论 ART在胎儿期就已经表现出心脏形态及功能的改变,在早期发现这一改变,能够给临床的早期干预提供重要依据。
[Abstract]:Objective to investigate the changes of cardiac morphology and function in ART pregnant fetus by comparing the heart morphology and function between the pregnant fetus and the natural conception fetus by assisted fertility technique (art). Methods Fetal echocardiography was performed in 35 cases of ART pregnant women matched with gestational age and gestational week and 35 cases of naturally conceived pregnant women. The cardiac morphology and cardiac function indexes were recorded in the two groups. Results the fetus in ART group showed cardiovascular remodeling, including enlarged area of left and right atrium, decreased spherical and spherical index of left and right ventricle, increased thickness of free wall of left ventricle, interventricular septum, thickness of free wall of right ventricle, widening of aorta and pulmonary artery. Left ventricular FS decreased, left ventricular Tei index increased, mitral valve, tricuspid annulus displacement decreased, mitral valve, tricuspid valve E peak deceleration time decreased. Conclusion ART has shown changes in cardiac morphology and function at the fetal stage, and finding this change in the early stage can provide important evidence for early clinical intervention.
【作者单位】：首都医科大学附属北京安贞医院先天性心脏病母胎医学会诊中心;首都医科大学附属北京安贞医院超声诊断科;
【基金】：国家自然科学基金(No.81171350) 北京市自然科学基金(No.7122059) 国际科技合作专项项目(No.2013DFG32310)
【分类号】：R445.1;R714.5

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