单指数及双指数模型DWI在肺孤立性病变诊断效能的对比研究

发布时间：2018-10-07 18:24

【摘要】：目的对肺孤立性病变(SPLs)进行常规扩散加权成像(DWI)、体素内不相干运动扩散加权成像(IVIMDWI),明确单指数及双指数模型DWI在良恶性SPLs的诊断效能。方法前瞻性搜集经病理证实的62例SPLs(恶性肿瘤51例;良性病变11例),术前均行MRI平扫、DWI及IVIM-DWI。DWI扫描b值=0、600 s/mm~2,IVIMDWI采取13个b值(0、5、10、15、20、25、50、80、150、300、500、800、1000 s/mm~2)。应用受试者操作特征(ROC)曲线分析ADC、D、D~*及f值诊断效能。结果 51例恶性肿瘤D值为(0.92±0.20)×10-3mm~2/s,11例良性病变D值为(1.39±0.36)×10~(-3)mm~2/s,两者差异有统计学意义(P=0.001);恶性肿瘤f值为(16.02±8.7)%,良性病变f值为(20.72±8.75)%,两者差异无统计学意义(P=0.315);恶性肿瘤D~*值为(11.04±5.75)×10~(-3)mm~2/s,良性病变D*值为(9.79±5.27)×10~(-3)mm~2/s,两者差异无统计学意义(P=0.467)。应用ROC曲线进行分析,得出D值的曲线下面积为0.858,ADC b=600 s/mm~2曲线下面积为0.802;D值鉴别良恶性病变的最佳阈值为1.25×10~(-3)mm~2/s,敏感性和特异性分别为98.11%和72.73%。结论对于SPLs的鉴别,双指数模型与单指数模型DWI均有价值,其中D值的诊断价值最大。
[Abstract]:Objective to evaluate the diagnostic efficacy of single index and double exponential models of (SPLs) in benign and malignant SPLs by conventional diffusion-weighted imaging (DWI),) with incoherent motion diffusion weighted imaging (IVIMDWI),). Methods Sixty-two patients with pathologically proved SPLs (malignant tumor 51 cases; benign lesion 11 cases) were prospectively studied. MRI plain scan DWI and IVIM-DWI.DWI scan (b value: 0 600 s / mm / 2 IVI DWI) were performed on 13 b values (0 0 / 10 1 / 10 15 ~ 20 ~ 25 / 50 ~ 20 ~ 250 ~ 50 ~ (50) ~ 80 / 150 / 150 ~ 500 ~ 800 s/mm~2) before operation. The diagnostic efficacy of ADC,D,D~* and f values was analyzed by using the (ROC) curve of operating characteristics of subjects. Results the D value of 51 malignant tumors was (0.92 卤0.20) 脳 10 ~ (-3) mm ~ (-2) / s, the D value of benign lesions was (1.39 卤0.36) 脳 10 ~ (-3) mm~2/s, (P0. 001), the f value of malignant tumors was (16. 02 卤8. 7) and the f value of benign lesions was (20. 72 卤8. 75), the difference of D value of malignant tumors was (11. 04 卤5. 75) 脳 10 ~ (-3) mm~2/s, benign lesions (P = 0. 315), and that of malignant tumors was (11. 04 卤5. 75) 脳 10 ~ (-3) mm~2/s,. There was no significant difference in D * value of lesion (9.79 卤5.27) 脳 10 ~ (-3) mm~2/s, between the two groups (P < 0. 467). The ROC curve was used to analyze the area under D value of 0.858ADCBX 600 s/mm~2 curve. The best threshold of D value was 1.25 脳 10 ~ (-3) mm~2/s, sensitivity and specificity were 98.11% and 72.73%, respectively. Conclusion double index model and single index model DWI are valuable for the differential diagnosis of SPLs, and D value is the most valuable for diagnosis.
【作者单位】：广州医科大学附属第一医院放射科;
【基金】：国家自然基金青年项目(编号:81601457) 广东省医学科研基金项目(编号:A2016410) 广州市科技计划项目(编号:201510010234) 广州市医药卫生科技项目(编号:20151A011066)
【分类号】：R445.2;R734.2

【相似文献】