超声导管肾去交感化的有效性及安全性
发布时间：2018-11-25 08:20
【摘要】：目的探索自行研发10.0 MHz超声导管以不同参数组合消融肾动脉周围神经时温度场的分布,并观察在体条件下不同剂量声能产生的去交感神经效果。方法超声导管消融犬离体肾动脉,以针式热电偶检测不同声功率消融不同时间时距肾动脉内膜不同距离处的温度。选择温度≥51℃的组合行活体消融。测量消融前及消融后1周的血压,取肾动脉及周围组织行病理学检查。结果肾动脉周围温度与消融功率及时间呈正相关,各组温度均在5 mm处达峰值。1.5 W×30s消融组、3.0 W×15s消融组及3.0 W×30s消融组在5mm、7mm处达有效消融温度。消融1周后消融组收缩压和舒张压下降幅度分别为(8.77±0.78)mmHg/(6.44±0.60)mmHg,(9.78±1.86)mmHg/(6.36±1.49)mmHg,(13.34±1.75)mmHg/(12.20±2.44)mmHg(P0.05)。肉眼观测肾动脉周围无损伤,HE染色见肾周围神经空泡样变。结论 10.0 MHz超声导管消融肾周围神经,在距内膜5~7mm处达有效温度;在体实验初步证明其应用于肾去交感的有效性及安全性。
[Abstract]:Objective to investigate the distribution of temperature field during the ablation of peripheral nerves of renal artery by 10 MHz ultrasound catheter with different parameters, and to observe the effect of different doses of sound energy on dessympathetic nerve in vivo. Methods Ultrasonic catheter ablation of isolated canine renal artery was performed and the temperature at different distances from the renal artery intima was measured by needle thermocouple. The combination of temperature 鈮，
本文编号：2355430
[Abstract]:Objective to investigate the distribution of temperature field during the ablation of peripheral nerves of renal artery by 10 MHz ultrasound catheter with different parameters, and to observe the effect of different doses of sound energy on dessympathetic nerve in vivo. Methods Ultrasonic catheter ablation of isolated canine renal artery was performed and the temperature at different distances from the renal artery intima was measured by needle thermocouple. The combination of temperature 鈮，
本文编号：2355430
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