肌酸代谢的化学交换饱和位移成像:3.0T MRI初步研究
发布时间：2018-11-28 11:26
【摘要】：目的探讨3.0T MRI化学交换饱和位移成像技术(chemical exchange saturation transfer,CEST)对肌酸代谢成像的可行性及相关影响因素。方法准备不同浓度肌酸及其代谢产物的体外模型和不同pH值的肌酸及其对照组体外模型。采用3.0T MRI对这两组模型进行CEST成像,通过CEST效应及Z谱进行量化分析。结果 3.0T MRI可检测到不同浓度肌酸之间信号(±1.8ppm)差异明显(F=99.08,P0.001),且信号强度随着浓度增加而增强(r=0.963,P0.001)。另外,不同pH值环境CEST效应差异明显(F=5.539,P=0.002),信号随pH值下降而逐渐减低(r=0.41,P=0.035)。结论 3.0T MRI进行CEST成像评价肌酸代谢是可行的,且其CEST效应受肌酸浓度及代谢环境pH值等因素影响。
[Abstract]:Objective to investigate the feasibility and related factors of 3.0T MRI chemical-exchange saturated displacement imaging (chemical exchange saturation transfer,CEST) on creatine metabolism imaging. Methods in vitro models of creatine and its metabolites with different concentrations of creatine and creatine with different pH values were prepared. The CEST imaging of the two groups of models was performed with 3.0T MRI, and the CEST effect and Z spectrum were analyzed quantitatively. Results the signal (卤1.8ppm) of creatine at different concentrations could be detected by 3.0T MRI, and the signal intensity was increased with the increase of concentration (r = 0.963, P 0.001). In addition, there were significant differences in CEST effect among different pH values (FV 5.539 P0. 002), and the signal decreased gradually with the decrease of pH value (r 0. 41% P0. 035). Conclusion it is feasible to evaluate creatine metabolism by CEST imaging with 3.0T MRI, and its CEST effect is affected by creatine concentration and pH value of metabolic environment.
【作者单位】： 四川大学华西第二医院放射科妇儿疾病与出生缺陷教育部重点实验室;四川大学华西医院放射科;贵州遵义医学院附属医院影像科;西门子医疗东北亚磁共振科研合作部;西门子澳大利亚有限公司医疗事业部;
【基金】：国家自然科学基金(No.81471721) 教育部新世纪优秀人才支持计划(No.NCET-13-0386) 四川省应用基础研究项目(No.2014JY0157) 成都市科技惠民项目(No.2014-HM01-00077-SF)资助
【分类号】：R445.2
，
本文编号：2362694
[Abstract]:Objective to investigate the feasibility and related factors of 3.0T MRI chemical-exchange saturated displacement imaging (chemical exchange saturation transfer,CEST) on creatine metabolism imaging. Methods in vitro models of creatine and its metabolites with different concentrations of creatine and creatine with different pH values were prepared. The CEST imaging of the two groups of models was performed with 3.0T MRI, and the CEST effect and Z spectrum were analyzed quantitatively. Results the signal (卤1.8ppm) of creatine at different concentrations could be detected by 3.0T MRI, and the signal intensity was increased with the increase of concentration (r = 0.963, P 0.001). In addition, there were significant differences in CEST effect among different pH values (FV 5.539 P0. 002), and the signal decreased gradually with the decrease of pH value (r 0. 41% P0. 035). Conclusion it is feasible to evaluate creatine metabolism by CEST imaging with 3.0T MRI, and its CEST effect is affected by creatine concentration and pH value of metabolic environment.
【作者单位】： 四川大学华西第二医院放射科妇儿疾病与出生缺陷教育部重点实验室;四川大学华西医院放射科;贵州遵义医学院附属医院影像科;西门子医疗东北亚磁共振科研合作部;西门子澳大利亚有限公司医疗事业部;
【基金】：国家自然科学基金(No.81471721) 教育部新世纪优秀人才支持计划(No.NCET-13-0386) 四川省应用基础研究项目(No.2014JY0157) 成都市科技惠民项目(No.2014-HM01-00077-SF)资助
【分类号】：R445.2
，
本文编号：2362694
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