血清蛋白磷酸酯酶2A水平测定在宫颈癌诊断中的应用

发布时间：2017-12-27 06:02

本文关键词：血清蛋白磷酸酯酶2A水平测定在宫颈癌诊断中的应用　出处：《中国临床新医学》2016年12期 　论文类型：期刊论文

【摘要】：目的分析宫颈癌患者血清蛋白磷酸酯酶2A(PP2A)的水平及活性变化,为临床早期诊断提供参考依据。方法选取该院就诊的32例宫颈癌患者和高危人乳头瘤病毒(hs HPV)感染者30例,同期选取体检健康女性30名作为对照组,采用酶联免疫吸附法测定入组对象PP2A水平,并通过酶活性测定试剂盒对PP2A活性进行测定。结果 hs HPV组和宫颈癌组血清PP2A水平及活性显著低于对照组(P0.05),且宫颈癌组PP2A水平及活性显著低于hs HPV组(P0.05)。结论宫颈癌患者血清PP2A表达水平和酶活性均下降,PP2A可作为临床早期诊断宫颈癌的实验室检查潜在标志物。
[Abstract]:Objective to analyze the level and activity of serum protein phosphatase 2A (PP2A) in patients with cervical cancer, and to provide a reference for the early diagnosis of clinical diagnosis. Methods the hospital 32 cases of patients with cervical cancer and human papillomavirus (HS HPV) 30 cases of infection, 30 healthy women were selected as control group, the determination of subjects PP2A level by ELISA kit, and the activity of PP2A were determined by enzyme activity determination. Results serum PP2A level and activity in HS HPV group and cervical cancer group were significantly lower than those in control group (P0.05), and the level and activity of PP2A in cervical cancer group were significantly lower than those in HS HPV group (P0.05). Conclusion the serum levels of PP2A and enzyme activity in patients with cervical cancer are decreased, and PP2A can be used as a potential marker for the early diagnosis of cervical cancer in the laboratory.
【作者单位】：青岛市第三人民医院检验科;青岛市市南区八大湖街道巢湖路社区卫生服务中心;青岛市立医院检验科;
【分类号】：R737.33;R730.43
【正文快照】： (余彩明);266000山东,青岛市立医院检验科(杨晶)宫颈癌(cervical cancer)是除乳腺癌外女性最常见的恶性肿瘤。随着人们生活水平的提高和个人卫生情况的改善以及宫颈细胞学筛查的推广,其发病率曾一度下降。但有研究指出,由于诸多因素如不注重宫颈癌的筛查,过早接触性生活,慢性

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