基础窦卵泡数预测IVF患者临床妊娠结局的Meta分析

发布时间：2017-12-28 05:08

  本文关键词：基础窦卵泡数预测IVF患者临床妊娠结局的Meta分析　出处：《医学研究杂志》2016年09期 　论文类型：期刊论文

  更多相关文章： 基础窦卵泡数 妊娠结局 Meta分析

【摘要】：目的通过Meta分析探讨基础窦卵泡数预测IVF妊娠结局的临床应价值。方法收集国内外有关基础窦卵泡数与IVF-ET临床妊娠结局的相关研究,符合纳入与排除标准的相关文献共11篇,采用Rev Man5.2软件对纳入的文献进行Meta分析。结果通过对纳入的11项研究进行Meta分析显示,基础窦卵泡数越多,获卵数、临床妊娠率、继续妊娠率、种植率越高,差异有统计学意义。获卵数(SMD合并=-0.87,95%CI:-1.22~-0.52;Z=4.84,P=0.000),临床妊娠率(OR合并=0.62,95%CI:0.54~0.72,Z=6.19,P=0.000)继续妊娠率(OR合并=0.21,95%CI:0.08~0.59,Z=3.00,P=0.003);种植率(OR合并=0.59,95%CI:0.49~0.72,Z=5.31,P=0.000),结果表明,基础窦卵泡数越多,获卵数和临床妊娠率就越高。结论基础窦卵泡数可能是体外受精前量化卵巢储备功能的有利检测指标,并直接影响临床妊娠结局。
[Abstract]:Objective to explore the clinical value of predicting the outcome of IVF pregnancy by analyzing the number of basal sinus follicles by Meta analysis. Methods a total of 11 related literatures on the number of basal sinus follicles and IVF-ET clinical pregnancy outcomes were collected. There were a total of 11 articles that met the inclusion and exclusion criteria. Rev Man5.2 software was used to conduct the Meta analysis of the included literatures. Results Meta analysis of 11 studies showed that the higher the number of follicles in basal sinus, the higher the number of ovum, clinical pregnancy rate, continuing pregnancy rate and implantation rate. The number of oocytes (SMD and =-0.87,95%CI:-1.22~-0.52; Z=4.84, P=0.000), the clinical pregnancy rate (OR and =0.62,95%CI:0.54~0.72, Z=6.19, P=0.000) on pregnancy rate (OR and =0.21,95%CI:0.08~0.59, Z=3.00, P=0.003); implantation rate (OR and =0.59,95%CI:0.49~0.72, Z=5.31, P=0.000). The results show that the number of antral follicle number, the number of oocytes and clinical the pregnancy rate is higher. Conclusion the number of basal sinus follicles may be a favorable indicator for quantifying ovarian reserve before in vitro fertilization and directly affects the outcome of clinical pregnancy.
【作者单位】： 中国武警总医院妇产科;
【分类号】：R714.8
【正文快照】： 自1978年英国剑桥的Steptoe和Edwards教授合作,应用体外受精-胚胎移植技术孕育的世界第1例试管婴儿Louis Brown诞生,辅助生殖技术技术已经成为不孕不育的主要治疗手段[1]。但是近10~20年来,ART技术的成功率并没有大的突破,宫腔内人工授精(IUI)的妊娠率为7.4%~12.6%,而IVF/ICSI，

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