控制性超促排卵刺激中子宫内膜息肉对体外受精-胚胎移植妊娠结局的影响

发布时间：2017-12-28 06:23

本文关键词：控制性超促排卵刺激中子宫内膜息肉对体外受精-胚胎移植妊娠结局的影响　出处：《生殖与避孕》2016年02期 　论文类型：期刊论文

【摘要】：目的:探讨在控制性超促排卵(controlled ovarian hyperstimulation,COH)刺激过程中新诊断的子宫内膜息肉(endometrial polyp,EP)对体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)新鲜周期妊娠结局的影响。方法:选择行IVF/ICSI-ET新鲜周期的3 003例患者的3 003个周期进行回顾性分析。IVF/ICSI-ET术前行相关检查诊断宫腔形态正常,根据在COH过程中是否新发现EP将其分为研究组(新发现息肉,n=60)和对照组(未发现息肉,n=2 943)。观察患者妊娠结局。结果:患者的临床妊娠率、自然流产率、继续妊娠率组间比较,差异均无统计学意义(P0.05)。研究组和对照组生化妊娠率(20.0%vs 9.8%)、异位妊娠率(3.3%vs 0.1%),差异有统计学意义(P=0.035,P0.000 1)。结论:在COH刺激过程中新诊断的与生化妊娠和异位妊娠的发生相关,但不影响IVF-ET新鲜周期的最终临床妊娠率、继续妊娠率以及早期流产率的发生。
[Abstract]:Objective: To explore the effects of controlled ovarian hyperstimulation (controlled ovarian, hyperstimulation, COH) of endometrial polyps diagnosed during stimulation (endometrial polyp, EP) on in vitro fertilization / intracytoplasmic sperm injection embryo transfer (IVF/ICSI-ET) effect of pregnancy outcome in the fresh cycle. Methods: a retrospective analysis was performed in 3003 cycles of 3003 patients who underwent IVF/ICSI-ET fresh cycle. Preoperative diagnosis was performed by IVF/ICSI-ET. The morphology of uterine cavity was normal. According to whether COH was found in EP, it was divided into study group (New polyp, n=60) and control group (not found polyp, n=2 943). The outcome of the pregnancy was observed. Results: there was no significant difference between the patients' clinical pregnancy rate, natural abortion rate and continuous pregnancy rate (P0.05). The rate of biochemical pregnancy (20.0%vs 9.8%) and the rate of ectopic pregnancy (3.3%vs 0.1%) in the study group and the control group were statistically significant (P=0.035, P0.000 1). Conclusion: in the process of COH stimulation, the new diagnosis is related to the occurrence of biochemical pregnancy and ectopic pregnancy, but does not affect the final clinical pregnancy rate, continuous pregnancy rate and early abortion rate of IVF-ET.
【作者单位】：甘肃省妇幼保健院生殖医学中心;
【基金】：甘肃省科技厅支撑计划项目(1104FKCA145)
【分类号】：R714.8
【正文快照】： 子宫内膜息肉(endometrial polyp,EP)是由于子宫内膜局灶性增生引起的宫腔内良性病变,其在不孕妇女中检出率高,但EP对生殖功能的影响机制尚不完全清楚。不孕患者EP对体外受精-胚胎移植(IVF-ET)妊娠结局的影响在临床上受到较多关注[1-3],但临床上EP合并不孕患者在什么时机施行I

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