醋酸亮丙瑞林微球治疗子宫内膜异位症效果研究

发布时间：2018-01-02 19:29

本文关键词：醋酸亮丙瑞林微球治疗子宫内膜异位症效果研究　出处：《中国性科学》2016年11期 　论文类型：期刊论文

【摘要】：目的:观察醋酸亮丙瑞林微球治疗子宫内膜异位症的效果及对患者CA125水平的影响,旨在为子宫内膜异位症患者术后选择巩固药物治疗提供科学依据。方法:选取子宫内膜异位症患者86例作为研究对象。均经腹腔镜术后病理组织学确诊,随机分为实验组和对照组,每组各43例。实验组给予醋酸亮丙瑞林微球治疗。对照组给予口服避孕药达英-35治疗。观察并比较两组患者的疗效及药物不良反应的发生情况,测定患者外周血CA125水平。结果:两组患者的总有效率无统计学差异(P0.05)。停药后6个月,实验组无复发,对照组出现4例复发,复发率有统计学差异(P0.05)。治疗前,两组患者的CA125水平无统计学差异,治疗后,两组患者的CA125均较治疗前降低,差异有统计学意义(P0.05)。治疗前,实验组与对照组患者性激素水平无统计学差异(P0.05),治疗后,实验组与对照组患者性激素水平均较治疗前降低,且实验组水平均低于对照组,差异有统计学意义(P0.01)。两组之间的不良反应发生率无统计学差异(P0.05)。结论:醋酸亮丙瑞林微球治疗子宫内膜异位症的疗效确切,复发率低,可降低血清CA125水平以阻滞疾病进展,虽有部分不良反应,但多为低雌激素症状,且程度较轻,可进一步临床推广。
[Abstract]:Objective: To observe the effect of leuprolide acetate microspheres in the treatment of endometriosis and its effect on the CA125 level of patients, to surgery in patients with endometriosis after drug treatment to provide a scientific basis for consolidation. Methods: 86 cases of endometriosis patients as the research object. By pathology after laparoscopic surgery, were randomly divided into as the experimental group and control group, 43 cases in each group. The experimental group received leuprolide acetate microspheres treatment. The control group was given oral contraceptives with -35 treatment. The efficacy was observed and compared between the two groups of patients and drug adverse reaction conditions, the determination of the level of CA125 in peripheral blood. Results: two groups of patients with total efficiency no statistical difference (P0.05). 6 months after discontinuation of the experimental group, control group had no recurrence, 4 cases of recurrence, the recurrence rate was statistically difference (P0.05). Before treatment, two groups of patients with no statistical CA125 level The difference, after treatment, the CA125 of two groups were lower than before treatment, the difference was statistically significant (P0.05). Before treatment, the experimental group and the control group of patients with sex hormone level was not statistically significant (P0.05). After treatment, the experimental group and the control group decreased serum hormone levels were lower than before treatment, and the water of experimental group were lower than those in control group, the difference was statistically significant (P0.01). The adverse reactions between the two groups there was no significant difference (P0.05). Conclusion: the effect of leuprolide acetate microspheres in treatment of endometriosis is effective, low recurrence rate, can block the progression of the disease reduced the serum level of CA125, though the adverse reaction part, but is the low estrogen symptoms, and to a lesser extent, can be further popularized.

【作者单位】：西安高新医院产三科;
【分类号】：R711.71
【正文快照】： 研究对象。均经腹腔镜术后病理组织学确诊,随机分为实验组和对照组,每组各43例。实验组给予醋酸亮丙瑞林微球治疗。对照组给予口服避孕药达英-35治疗。观察并比较两组患者的疗效及药物不良反应的发生情况,测定患者外周血CA125水平。结果:两组患者的总有效率无统计学差异(P0.0

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