曲普瑞林治疗对子宫内膜异位症不孕腹腔镜术患者疗效及血清性激素的影响

发布时间：2018-01-04 08:31

本文关键词：曲普瑞林治疗对子宫内膜异位症不孕腹腔镜术患者疗效及血清性激素的影响　出处：《中国医学创新》2016年31期 　论文类型：期刊论文

【摘要】：目的:探讨曲普瑞林治疗对子宫内膜异位症不孕腹腔镜术患者疗效及血清性激素的影响。方法:选取2012年6月-2015年1月期间本院确诊治疗的子宫内膜异位症不孕患者124例,依据随机分配原则分为联合组和三酮组,每组62例。两组患者均给予常规腹腔镜下剥除术治疗,术后三酮组患者在此基础上给予2.5 mg孕三烯酮口服治疗,联合组患者在此基础上给予3.75 mg曲普瑞林肌注治疗。采用酶联免疫吸附法(ELISA)检测血清雌二醇(E2)、卵泡刺激素(FSH)和黄体生成素(LH)水平,随访1年,统计分析所有患者临床疗效,治疗前后血清E2、FSH和LH水平及不良反应发生情况。结果:联合组患者治疗总有效率和受孕率明显高于三酮组,两组比较差异均有统计学意义(P0.05)。治疗后,联合组患者E2、FSH和LH水平明显低于三酮组,两组比较差异均有统计学意义(P0.05)。联合组和三酮组不良反应发生率分别为6.45%、9.68%,前者低于后者,但两组比较差异无统计学意义(P0.05)。结论:曲普瑞林治疗可有效改善子宫内膜异位症不孕腹腔镜术患者血清E2、FSH和LH水平,提高患者的临床疗效,且具有良好的安全性,值得临床进一步推广。
[Abstract]:Objective: to investigate the effect of triplatin on the efficacy and serum sex hormone of infertile patients with endometriosis. A total of 124 infertile patients with endometriosis were selected from June 2012 to January 2015. According to the principle of random distribution, they were divided into combined group and triketone group with 62 cases in each group. The patients in both groups were treated with conventional laparoscopic excision. The patients in the trione group were given 2.5 mg of pregnenone orally on this basis. On this basis, the patients in the combined group were given 3.75 mg triplatin intramuscularly. Serum estradiol E2 was detected by enzyme linked immunosorbent assay (Elisa). The levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were followed up for one year. Results: the total effective rate and pregnancy rate of the combined group were significantly higher than that of the trione group, and the difference between the two groups was statistically significant (P 0.05). The levels of E2FSH and LH in the combined group were significantly lower than those in the trione group, and the difference between the two groups was statistically significant (P 0.05). The incidence of adverse reactions in the combined group and the trione group was 6.45% respectively. 9.68, the former is lower than the latter, but there is no significant difference between the two groups. Conclusion: troplatin treatment can effectively improve the serum E2 of infertile patients with endometriosis. The levels of FSH and LH can improve the clinical efficacy of patients and have good safety, which is worthy of further clinical promotion.
【作者单位】：广东省深圳市龙华新区中心医院;广东省深圳市罗湖区人民医院;
【基金】：广东省医学科研项目(A2014642) 深圳市龙华新区科技项目(20160523A1030148)
【分类号】：R713.4
【正文快照】： 子宫内膜异位症是临床上常见的妇科疾病之8例。三酮组年龄21~40岁,平均(31.21±4.87)岁;一,由有活性的内膜细胞种植在子宫内膜以外的位不孕时间1~8年,平均(3.67±1.21)年;R-AFS置所致,可导致月经异常、性交疼痛、不孕等症状,分类分为Ⅰ期23例,Ⅱ期33例,Ⅲ期6例。本研究严重影

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