门冬胰岛素治疗妊娠糖尿病的临床效果研究

发布时间：2018-01-05 01:05

本文关键词：门冬胰岛素治疗妊娠糖尿病的临床效果研究　出处：《药品评价》2016年21期 　论文类型：期刊论文

【摘要】：目的:研究门冬胰岛素治疗妊娠糖尿病的临床效果。方法:选择来自江西省赣州市南康区第一人民医院2014年2月至2015年12月妊娠糖尿病患者100例。100例妊娠糖尿病患者随机分为常规人胰岛素组和门冬胰岛素组。所有患者均常规给予饮食控制,并增加运动量。在此基础上,常规人胰岛素组给予常规人胰岛素进行治疗,在三餐前半小时进行皮下注射;门冬胰岛素组给予门冬胰岛素进行治疗,在早、晚餐前5min进行皮下注射。比较两组患者治疗总有效率;血糖达标时间、胰岛素每天平均用量、治疗时间;用药前和用药后患者空腹血糖、餐后2h血糖、糖化血红蛋白(HbA_(1c))的差异;剖宫产率、羊水过多、胎膜早破、巨大儿等妊娠结局的差异。结果:门冬胰岛素组相较于常规人胰岛素组治疗总有效率更高,P0.05;门冬胰岛素组相较于常规人胰岛素组血糖达标时间、胰岛素每天平均用量、治疗时间更少,P0.05;用药前两组空腹血糖、餐后2h血糖、糖化血红蛋白相似,P0.05;用药后门冬胰岛素组相较于常规人胰岛素组空腹血糖、餐后2h血糖、Hb A1c改善更显著,P0.05。门冬胰岛素组剖宫产率、羊水过多、胎膜早破、巨大儿等的发生率明显低于常规人胰岛素组,P0.05。结论:门冬胰岛素治疗妊娠糖尿病的临床效果确切,可有效降低产妇血糖水平,促进血糖达标,减少胰岛素用量和治疗时间,降低剖宫产率,改善母婴结局,值得推广。
[Abstract]:Objective: To study the clinical effect of insulin aspart treatment of gestational diabetes mellitus. Methods: from Nankang District in Jiangxi province Ganzhou city first people's Hospital from February 2014 to December 2015, 100 cases of.100 patients with gestational diabetes mellitus patients with gestational diabetes were randomly divided into routine insulin group and insulin group. All patients door in winter were given routine diet control, and increase the amount of exercise. On this basis, regular human insulin group was given conventional insulin treatment, subcutaneous injection in the first half hour meals; insulin aspart group received insulin aspart treatment in early 5min subcutaneous injection before dinner. Compared two groups of patients with the total efficiency of treatment; time of blood glucose, insulin dosage per day, treatment time; fasting blood glucose before and after medication, 2h postprandial blood glucose, glycosylated hemoglobin (HbA_ (1c)) the difference; the rate of cesarean section, polyhydramnios, fetal Premature rupture of membranes, differences in pregnancy outcomes macrosomia. Results: insulin aspart group compared with the conventional insulin treatment group total efficiency is higher, P0.05; insulin aspart group compared to conventional insulin group time of blood glucose, insulin dosage per day, less treatment time, P0.05; before treatment two groups of fasting blood glucose, 2h postprandial blood glucose, glycosylated hemoglobin, P0.05; insulin aspart group after treatment compared with regular human insulin group, fasting blood glucose, 2h postprandial blood glucose, Hb A1c significantly improved P0.05., insulin aspart group cesarean section rate, polyhydramnios, premature rupture of membranes, the incidence of macrosomia was significantly lower than that of regular human insulin group. Conclusion: insulin aspart P0.05. exact therapeutic effect for the treatment of gestational diabetes, which can effectively reduce the maternal blood glucose level, promote blood glucose, reduce insulin dosage and treatment time, reduce the rate of cesarean section, improve maternal and infant. The bureau is worth promoting.

【作者单位】：江西省赣州市南康区第一人民医院;
【分类号】：R714.256
【正文快照】： 妊娠糖尿病为既往无糖尿病或无出现糖耐量减低的妇女于妊娠期间第一次出现一定程度的糖耐量减低现象,妊娠糖尿病在妊娠中晚期妇女中发病率较高,其对孕产妇和胎儿均可造成不良影响。有研究显示,妊娠糖尿病患者若治疗不及时或不规范,可导致羊水增多、尿路感染、胎膜早破和巨大儿

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