血清CA125、EMAb联合检测对子宫腺肌病诊断价值的ROC曲线评价

发布时间：2018-01-04 22:29

本文关键词：血清CA125、EMAb联合检测对子宫腺肌病诊断价值的ROC曲线评价　出处：《中国妇幼保健》2016年23期 　论文类型：期刊论文

【摘要】：目的采用ROC曲线评价血清CA125、EMAb联合检测对子宫腺肌病的诊断价值。方法选取2014年11月-2015年10月该院确诊的子宫腺肌病患者48例为观察组,另选同期拟于该院体检的健康女性45例为对照组。采用酶联免疫吸附法(ELISA)检测两组血清中EMAb水平,采用放射免疫法(RIA)测定两组血清中的CA125水平。比较两组血清CA125、EMAb水平,同时采用Roc曲线分析血清CA125、EMAb单独及联合检测对子宫腺肌病的诊断价值。结果观察组的EMAb水平和CA125水平明显高于对照组,差异有统计学意义(P0.05)。ROC曲线分析结果显示,血清CA125、EMAb联合预测子宫腺肌病的ROC曲线下面积、灵敏度、特异度分别为0.937、95.92%和97.73%,血清CA125、EMAb单独预测子宫腺肌病的ROC曲线下面积分别为0.832和0.797,灵敏度分别为93.75%和91.30%,特异度分别为93.33%和87.23%,二者联合检测的ROC曲线下面积、灵敏度和特异度明显较高(P0.05)。结论血清CA125、EMAb水平检测对子宫腺肌病的辅助诊断价值良好,二者联合检测有利于提高诊断子宫腺肌病的准确性,血清CA125、EMAb水平可作为诊断子宫腺肌病的参考指标。
[Abstract]:Objective to evaluate serum CA125 by ROC curve. Methods 48 cases of adenomyosis diagnosed in our hospital from November 2014 to October 2015 were selected as the observation group. In addition, 45 healthy women were selected as control group. Elisa was used to detect serum EMAb level in both groups. Serum CA125 levels were measured by radioimmunoassay (RIA), serum CA125 Emab levels were compared, and serum CA125 levels were analyzed by Roc curve. Results the levels of EMAb and CA125 in the observation group were significantly higher than those in the control group. The difference was statistically significant (P 0.05) .ROC curve analysis showed that serum CA125 Emab combined to predict the area and sensitivity under the ROC curve of adenomyosis. The specificity was 0.937% and 97.73%, respectively. Serum CA125. The area under the ROC curve of EMAb alone was 0.832 and 0.797, and the sensitivity was 93.75% and 91.30% respectively. The specificity was 93.33% and 87.23, respectively. The area, sensitivity and specificity of the combined detection of ROC were significantly higher than that of P0.050.Conclusion Serum CA125. The detection of EMAb level is of good value in the auxiliary diagnosis of adenomyosis. The combined detection of the two levels is helpful to improve the accuracy of diagnosis of adenomyosis and serum CA125. EMAb level can be used as a reference index for diagnosis of adenomyosis.
【作者单位】：南昌市生殖医院;
【分类号】：R711.71
【正文快照】： 子宫腺肌病属于子宫内膜异位症的一种特殊类型[1-2],其常见的临床症状表现为痛经、月经失调,多发于40岁以上妇女群体,是一种常见的妇科疾病[3]。子宫腺肌病发病机制目前尚不明确,要根治有一定的难度,因而做好其监测和预防极其必要[4]。且子宫腺肌病和子宫腺肌瘤在临床症状上有

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