绝经前、后子宫内膜癌患者病理特点、细胞分化及预后比较

发布时间：2018-01-04 15:08

本文关键词：绝经前、后子宫内膜癌患者病理特点、细胞分化及预后比较　出处：《河南医学研究》2016年11期 　论文类型：期刊论文

【摘要】：目的研究绝经前、后子宫内膜癌患者病理特点、细胞分化及预后。方法回顾性分析2008年1月至2010年7月于周口市中医院就诊的102例子宫内膜癌患者临床病历资料,其中绝经前患者44例,绝经后患者58例。比较两组患者临床病理特点、细胞分化程度及预后。结果绝经前组患者例数显著低于绝经后组(P0.05),绝经前组非子宫内膜样腺癌、组织学分级为Ⅱ、Ⅲ级及无宫颈浸润患者例数显著少于绝经后组(P0.05),而中高分化和肌层浸润深度小于1/2患者例数显著多于绝经后组(P0.05)。绝经前组发生淋巴结、宫颈、附件及多器官转移的例数均少于绝经后组,但差异无统计学意义(P0.05)。绝经前组5年生存率为88.64%,绝经后组为87.93%,差异无统计学意义(P0.05)。结论子宫内膜癌好发于绝经后女性,且绝经后女性患者细胞分化程度低,恶性程度高,预后较差。但子宫内膜癌发病有年轻化趋势,临床应警惕月经紊乱等子宫内膜癌的早期症状,早期诊断,及时干预治疗,可获得较好预后。
[Abstract]:Objective to study after menopause, endometrial carcinoma, pathological characteristics, cell differentiation and prognosis. Methods a retrospective analysis from January 2008 to July 2010 in Zhoukou Hospital of Traditional Chinese Medicine for treatment of 102 cases of endometrial cancer patients with clinical data, including 44 cases of premenopausal patients, 58 patients after menopause. Comparison of two groups of patients with clinical pathological characteristics, cell differentiation and the prognosis of premenopausal group. Results the number of patients was significantly lower than that in the postmenopausal group (P0.05), the group of premenopausal non endometrioid adenocarcinoma, histological grade II, III grade and non invasive cervical patients were significantly less than that after group (P0.05), and high differentiation and myometrial invasion depth is less than 1/2 the number of patients was significantly higher than postmenopausal group (P0.05). Menopause occurred before the group of cervical lymph nodes, and attachments and multiple organ metastasis cases were less than the postmenopausal group, but the difference was not statistically significant (P0.05). The vast group before the 5 year survival rate was 88 .64%, postmenopausal group was 87.93%, the difference was not statistically significant (P0.05). Conclusion endometrial cancer occurs in postmenopausal women, and the degree of cell differentiation in patients with postmenopausal women with low, high degree of malignancy and poor prognosis of endometrial cancer. But the younger, early diagnosis and clinical symptoms of menstrual disorders, alert such as endometrial cancer, timely intervention, can obtain good prognosis.

【作者单位】：周口市中医院病理科;
【分类号】：R737.33
【正文快照】： 子宫内膜癌是女性生殖器常见的恶性肿瘤,有资料显示,子宫内膜癌发病率占生殖道恶性肿瘤的30%,且仍有上升趋势[1]。目前,多数学者认为子宫内膜癌好发于绝经后女性,其预后多与肿瘤分化程度、病理特点等相关,而临床对绝经前女性子宫内膜癌研究相对较少[2]。本研究回顾性分析2008

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