晚发型子痫前期胎盘124例临床病理分析

发布时间：2018-01-06 15:26

本文关键词：晚发型子痫前期胎盘124例临床病理分析　出处：《诊断病理学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨124例晚发型子痫前期胎盘的临床病理特点及预后。方法参照子痫前期诊断标准进行分类,124例晚发型子痫前期病例分为轻度组(83例)和重度组(41例),对2组患者的一般临床资料、胎盘组织病理特点及围产结局进行分析、比较。结果两组病例中胎盘主要的镜下改变包括蜕膜血管病变、梗死、胎盘早剥和绒毛发育不良,其中胎盘绒毛发育不良的发生率最高,其次是胎盘梗死。轻度组中轻度蜕膜血管病的发病率为21.7%(18/83)、重度组中的发病率为56.1%(23/41),两组间比较有显著差异(P0.01)。轻度组中胎盘绒毛发育不良的发病率为40.9%(34/83),重度组为70.7%(29/41),两组间差异显著(P0.05)。轻度组中胎儿宫内生长受限的发生率为21.7%(18/83),重度组为41.5%(17/41),两组间差异显著(P0.05)。轻度组中胎儿存活率为98.8%(82/83),重度组为92.7%(38/41),两组间无明显差异(P0.05)。另外重度蜕膜血管病、胎盘梗死、脐带异常及合并糖尿病方面两组比较无明显差异。结论晚发型重度子痫前期组的胎儿宫内生长受限的发生率高于轻度组。两组间胎儿存活率无明显差异,子痫前期预后不良。晚发型重度子痫前期的部分围生结局差于轻度组。
[Abstract]:Objective to investigate the clinical pathological characteristics and prognosis of 124 cases of late onset preeclampsia. Methods to classify the reference standard in diagnosing pre eclampsia, 124 cases of late onset preeclampsia patients were divided into mild group (83 cases) and severe group (41 cases), the clinical data of 2 patients, pathological features of placenta and perinatal the outcome of analysis, comparison. Results two cases of placenta main pathological changes including decidual vasculopathy, infarction, placental abruption and villous dysplasia, which placental dysplasia was the highest, followed by placental infarction. Mild group in incidence of mild decidual vascular disease rate was 21.7% (18/83), the incidence of in the severe group was 56.1% (23/41), there was a significant difference between the two groups (P0.01). The mild group of placental dysplasia incidence was 40.9% (34/83), severe group was 70.7% (29/41), the difference between the two groups was significant (P0.05) in the mild group. Intrauterine growth restriction incidence rate was 21.7% (18/83), severe group was 41.5% (17/41), the difference between the two groups was significant (P0.05). In the group of mild fetal survival rate was 98.8% (82/83), severe group was 92.7% (38/41), no significant difference between the two groups (P0.05). In addition, severe ghost film vascular disease, placental infarction, aspects of umbilical cord abnormalities and two with diabetes group had no significant difference. Conclusion late onset severe preeclampsia group intrauterine growth retardation was higher than mild group. Two groups of fetal survival rate had no significant difference in preeclampsia prognosis. Late onset severe preeclampsia part of poor perinatal outcome in the mild group.

【作者单位】：海淀区妇幼保健院病理科;北京大学人民医院病理科;海淀区妇幼保健院产科;
【基金】：北京市海淀区科技项目(NO:S2013009)
【分类号】：R714.244
【正文快照】： 子痫前期(preeclampsia,PE)是一种妊娠期特有疾病,以高血压和蛋白尿为主要临床表现,威胁母儿健康,常伴发较高的孕产妇和围产儿病死率。对子痫前期的研究一直为产科领域所瞩目,且以往的关注热点多集中于子痫前期的病因、发病机制及治疗等方面,罕有关于其胎盘组织病理学特点等方

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