胚胎发育潜能低下患者的冻融策略选择

发布时间：2018-01-06 21:34

本文关键词：胚胎发育潜能低下患者的冻融策略选择　出处：《中国性科学》2016年11期 　论文类型：期刊论文

【摘要】：目的:比较胚胎发育潜能低下的患者在冻融周期中移植不同时期胚胎的妊娠结局,以优化其冻融策略。方法:回顾性分析2015年1月至10月于我院生殖医学中心治疗的57例常规体外受精(IVF)周期或卵胞浆内单精子注射(ICSI)周期中胚胎发育潜能低下患者的冻融周期临床资料。根据移植胚胎的时期分为分裂胚移植组(n=35)及囊胚移植组(n=22),比较两组的临床妊娠率、种植率及早期流产率。结果:冻融周期中,Day3分裂胚移植组与Day5囊胚移植组相比,临床妊娠率(65.71%vs.63.63%)和种植率(50.00%vs.52.27%)相近;早期流产率虽无统计学差异,但分裂胚移植组的早期流产率有明显高于囊胚移植组的趋势(8.7%vs.0)。结论:冻融周期中,对胚胎发育潜能低下的患者建议优选囊胚移植,以降低早期流产风险。本研究结果需扩大样本后进一步探讨,为优化冻融周期的妊娠结局提供新思路。
[Abstract]:Objective: to compare the pregnancy outcomes of embryo transplants in different stages in freeze-thaw cycles in patients with low embryonic development potential. Methods: from January 2015 to October, 57 cases of IVF cycles or intracytoplasmic sperm injection (ICSI) were analyzed retrospectively. Clinical data of frozen-thawing cycle in patients with hypodevelopment of embryo development during ICSI cycle. According to the period of embryo transfer, they were divided into two groups: divided into divided embryo transfer group and blastocyst transplantation group (n ~ (35)) and blastocyst transplantation group (n ~ (22)). Results: the clinical pregnancy rate, implantation rate and early abortion rate of the two groups were compared with those of the Day5 blastocyst transplantation group. The clinical pregnancy rate (65.71 vs 63.63) and the planting rate (50.00v s.52.27) were similar. Although there was no statistical difference in the rate of early abortion, the rate of early abortion in the split embryo transplantation group was significantly higher than that in the blastocyst transplantation group. Conclusion: in the freeze-thaw cycle, the rate of early abortion is 8.7vs.0. In order to reduce the risk of early abortion, it is suggested to select blastocysts for patients with low embryonic development potential. The results of this study need to be further explored after expanding the sample to provide a new idea for optimizing the pregnancy outcome of freezing and thawing cycle.
【作者单位】：南京大学医学院附属鼓楼医院生殖医学中心;
【基金】：国家自然科学基金培育项目(021414380067) 江苏省南京市医学科技发展课题(YKK15074) CREATE-默克雪兰诺中国生殖医学研究基金
【分类号】：R714.8
【正文快照】： 胚胎冻融技术作为辅助生殖领域中的一项常规技术,方法成熟,结果稳定,是临床治疗中常规的保存生育力方法,既可减少IVF患者反复接受激素刺激的超排卵治疗,又能够有效的解决剩余胚胎的去向问题,目前该技术已经成为唯一被北美生殖医学委员会认可的临床可开展的生育力保存方法[1-5]

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