中西药联合治疗原发性卵巢功能不全的临床研究

发布时间：2018-01-13 16:34

本文关键词：中西药联合治疗原发性卵巢功能不全的临床研究　出处：《中华中医药杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:观察中药及联合西药治疗对原发性卵巢功能不全患者生殖内分泌激素及卵巢体积的影响。方法:采用随机对照研究,将183例原发性卵巢功能不全的患者分为POI(primary ovarian insufficiency,POI)-1(10IU/L≤FSH40IU/L)及POI-2(FSH≥40IU/L)两大组,每组再分为治疗组和对照组。POI-1治疗组采用单纯中药妇科养荣胶囊治疗,POI-2治疗组采用中西医结合治疗方法,即芬吗通2mg+中药妇科养荣胶囊治疗,对照组POI-1和POI-2均采用芬吗通2mg周期治疗,疗程为3个月。比较两组患者的激素水平、卵巢体积变化、Kupperman评分变化。结果:中药及中西药联合治疗组在改善月经相关症状、卵巢功能围早衰期所致更年期症状Kupperman症状评分及性激素FSH、LH水平升高,优于单纯西药治疗(P0.01);在改善卵巢体积与西药对照组或中药对照组对比差异无统计学意义。结论:妇科养荣胶囊及联合芬吗通治疗POI疗效显著,优于单纯激素替代疗法。
[Abstract]:Objective: To observe the effect of traditional Chinese medicine combined with western medicine and treatment of primary ovarian insufficiency in patients with reproductive endocrine hormone and ovarian volume. Methods: a randomized controlled study, 183 cases of primary ovarian insufficiency were divided into POI (primary ovarian insufficiency POI -1 (10IU/L) and POI-2 (FSH40IU/L) FSH = 40IU/L) two groups, each group was randomly divided into treatment group and control group.POI-1 treatment group with Chinese traditional medicine fukeyangyan capsule treatment, POI-2 treatment group were treated with combined traditional Chinese and Western medicine treatment, namely femonston 2mg+ medicine fukeyangyan capsule treatment, control group POI-1 and POI-2 were using femonston 2mg cycles of treatment, treatment for 3 months. Compared two groups of patients with hormone levels and ovarian volume change, the change of Kupperman score. Results: the traditional Chinese medicine and Western medicine combined treatment group in improving the menstrual related symptoms, ovarian function in premature menopause symptoms during the period of Ku Pperman symptom score and sex hormone FSH, increased the level of LH is better than pure western medicine (P0.01); in improving the ovarian volume and the control group of Western medicine or Chinese medicine control group showed no significant difference. Conclusion: fukeyangyan capsule combined with femonston treatment POI significant effect, better than using hormone replacement therapy.

【作者单位】：复旦大学附属妇产科医院;
【正文快照】： 原发性卵巢功能不全(primary ovarian insufficiency,POI),以往被称为卵巢早衰(primary ovarian failure,POF),是指女性在40岁之前出现的原发或继发性闭经,并伴有高促性腺激素、低雌激素表现的综合征[1]。POI是一种多病因所致的卵巢功能低下,多数患者病因并不明确[2-3]。40岁

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