复发性流产合并抗磷脂抗体综合征诊疗进展

发布时间：2018-01-14 08:15

本文关键词：复发性流产合并抗磷脂抗体综合征诊疗进展　出处：《中国优生与遗传杂志》2016年05期 　论文类型：期刊论文

【摘要】：抗磷脂抗体综合征(Antiphospholipid syndrome,APS)是一组由抗磷脂抗体(Antiphospholipid antibodies,APA)介导,临床表现为反复动、静脉血栓形成、复发性流产等,实验室血清检查持续性抗磷脂抗体阳性为特征的自身免疫性疾病。抗磷脂抗体综合征病因涉及广泛,疾病临床表现多样,临床治疗主要以抗凝治疗为核心。目前国际上将与同一性伴侣连续发生两次或两次以上妊娠20w前的妊娠丢失称为复发性流产,其中约20%左右由抗磷脂抗体综合征引起。复发性流产为育龄期抗磷脂抗体综合征女性患者最常见临床表现,反复清宫治疗影响子宫内膜及远期妊娠,对育龄期女性身心造成负面影响。抗磷脂抗体综合征可造成严重产科并发症。因此,适当、适时治疗对于改善妊娠结局、提高女性生殖健康意义重大。目前虽然抗凝及免疫抑制及调节治疗可有效提高患者成功分娩率,但尚无标准化治疗规范。新的治疗方式正在不断探索中。本文综述了复发性流产合并抗磷脂抗体综合征的发病机制、疾病诊断及治疗情况,旨在为疾病的诊断和治疗提供参考及借鉴。
[Abstract]:Antiphospholipid syndrome of anti-phospholipid antibody syndrome. APS) is a group of antiphospholipid antibodies-mediated by antiphospholipid APA, clinical manifestations of recurrent arteriovenous thrombosis. Recurrent abortion and other autoimmune diseases characterized by persistent positive anti-phospholipid antibody in laboratory serum. The etiology of anti-phospholipid antibody syndrome is extensive and the clinical manifestations of the disease are diverse. Clinical treatment is mainly based on anticoagulant therapy. At present, two consecutive pregnancies with the same partner or more than two pregnancies before 20 weeks of pregnancy loss is called recurrent abortion. Recurrent abortion is the most common clinical manifestation of female patients with antiphospholipid antibody syndrome in childbearing age. Anti-phospholipid antibody syndrome can cause severe obstetric complications. Therefore, appropriate and timely treatment can improve the outcome of pregnancy. It is of great significance to improve the reproductive health of women. Although anticoagulant and immunosuppressive and regulatory therapy can effectively improve the rate of successful delivery of patients. However, there is no standardized treatment standard. New treatment methods are being explored. This article reviews the pathogenesis, disease diagnosis and treatment of recurrent abortion with anti-phospholipid antibody syndrome. The aim is to provide reference for diagnosis and treatment of disease.
【作者单位】：北京大学第三医院妇产科生殖医学中心教育部辅助生殖重点实验室北京市内分泌与辅助生殖重点实验室;
【分类号】：R714.21
【正文快照】： 抗磷脂抗体综合征是以全身动、静脉血栓形成为主要表现的自身免疫性疾病,疾病表现涉及全身多系统。目前我国男女患病率之比约为1∶9[1],育龄期女性多因反复出现妊娠丢失现象,于就诊过程中首次发现。目前国际上将与同一性伴侣连续两次或者两次以上出现妊娠20周前的妊娠丢失称为

【相似文献】