ANXA5和KDR启动子多态性与中国汉族妇女复发性流产遗传风险关联性分析

发布时间：2018-01-14 17:32

本文关键词：ANXA5和KDR启动子多态性与中国汉族妇女复发性流产遗传风险关联性分析　出处：《基因组学与应用生物学》2015年11期 　论文类型：期刊论文

【摘要】：为探讨ANXA5与KDR基因启动子区多态性是否为中国汉族妇女复发性流产的危险因素,我们应用测序的方法检测ANXA5-302TG(rs1050606)和KDR-607TC(rs55713360)多态性在RSA组(210例,病例组)和健康对照组(300例)中的基因型分布。检测结果:1 ANXA5-302TG 3种基因型在RSA组和健康对照组中的分布差异具有统计学意义(p0.05),携带GG、TG、GG+TG基因型,G等位基因,患RSA的相对风险分别增加(OR=3.043,p=0.049;OR=2.293,p=0.019;OR=2.448,p=0.006;OR=2.166,p=0.003);2 KDR-607TC 3种基因型在RSA组和健康对照组中的分布差异具有统计学意义(p0.05),携带CC基因型,C等位基因,患RSA的相对风险分别增加(OR=4.353,p=0.001;OR=2.113,p=0.001)。由此可见,分别携带ANXA5-302G,KDR-607C易感等位基因明显增加了RSA的患病风险。ANXA5-302TG,KDR-607TC多态性位点是中国汉族妇女患RSA的危险因素。
[Abstract]:In order to study the ANXA5 and KDR gene promoter polymorphism as a risk Chinese Han women recurrent abortion factors, we used the method of sequencing for detection of ANXA5-302TG (rs1050606) and KDR-607TC (rs55713360) polymorphism in the RSA group (210 cases, case group) and control group (300 cases) in genotype distribution. Results: the difference was statistically significant distribution of 1 ANXA5-302TG 3 genotypes in RSA group and healthy control group (P0.05), the TG, with GG, GG+TG genotype, G allele, the relative risk of RSA were increased (OR=3.043, p= 0.049; OR=2.293, p=0.019; OR=2.448, p=0.006; OR=2.166 p=0.003); the difference was statistically significant distribution of 2 KDR-607TC 3 genotypes in RSA group and healthy control group (P0.05), the CC genotype and C allele, the relative risk of RSA were increased (OR= 4.353, p=0.001; OR=2.113, p=0.001). Thus, articles respectively. The allele with ANXA5-302G and KDR-607C significantly increased the risk of RSA.ANXA5-302TG, and KDR-607TC polymorphism was a risk factor for RSA in Chinese Han women.

【作者单位】：重庆医科大学基础医学院;
【基金】：重庆市教委科研项目(KJ08030)资助
【分类号】：R714.21
【正文快照】： 复发性自然流产(recurrent spontaneous abortion,RSA)指在妊娠20周前连续发生3次或3次以上流产(Rah et al.,2012),近年来将连续发生2次或2次以上的自然流产也称为复发性流产。其发生率约占育龄妇女的1%~5%,为流产总数的15%~20%,是妊娠早期常见的并发症之一。RSA病因及其复杂,

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