新诊断多囊卵巢综合征患者Nesfatin-1水平变化及相关因素研究

发布时间：2018-01-14 23:31

本文关键词：新诊断多囊卵巢综合征患者Nesfatin-1水平变化及相关因素研究　出处：《中国现代医学杂志》2015年35期 　论文类型：期刊论文

【摘要】：目的探讨血清Nesfatin-1水平与多囊卵巢综合征(PCOS)的相关性。方法按PCOS的诊断标准选取61例患者为研究对象,分为超重组34例和正常体重组27例,并设健康女性为对照组。测定血清Nesfatin-1水平、空腹血糖(FBG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T),计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR),并对各指标间的相关性进行分析。结果正常体重组PCOS患者与对照组比较,FINS、HOMA-IR、LH、LH/FSH及T升高,Nesfatin-1水平降低;超重组PCOS患者与对照组比较,BMI、WHR、收缩压、舒张压、FPG、FINS、HOMA-IR、TG、TC、LDL-C、LH、LH/FSH及T升高,HDL-C、Nesfatin-1水平降低;超重组PCOS患者与正常体重组患者比较,BMI、WHR、收缩压、舒张压、FPG、FINS、HOMA-IR、TG、TC、LDL-C、LH、LH/FSH及T升高,HDL-C降低,而Nesfatin-1水平仅有降低趋势。相关分析显示,血清Nesfatin-1与BMI、FINS、HOMA-IR、LH、T呈负相关;多元线性回归分析表明,HOMA-IR、LH、T是影响血清Nesfatin-1水平的重要因素。结论新诊断PCOS患者Nesfatin-1水平降低,Nesfatin-1可能参与PCOS的发生、发展。
[Abstract]:Objective to investigate the correlation between serum Nesfatin-1 level and polycystic ovary syndrome (PCOS). The patients were divided into superrecombinant group (n = 34) and normal weight group (n = 27). Serum Nesfatin-1, fasting blood glucose (FBG) and fasting insulin (fins) were measured. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), luteinizing hormone (LH). Follicle stimulating hormone (FSH), testosterone (T), body mass index (BMI), waist-to-hip ratio (WHR) and insulin resistance index (HOMA-IRR) were calculated. Results compared with the control group, the FINSHOMA-IRN LHH / LH / FSH and T in normal weight group were higher than those in the control group. Nesfatin-1 level decreased; BMI-WHR, systolic blood pressure, diastolic blood pressure in patients with superrecombinant PCOS were compared with those in control group. LH/FSH and T increased the level of HDL-Cnesfatin-1. BMI-WHR, systolic blood pressure and diastolic blood pressure in patients with superrecombinant PCOS were compared with those in normal body weight group. LH/FSH and T increased, HDL-C decreased, while the level of Nesfatin-1 decreased. Correlation analysis showed that serum Nesfatin-1 and BMIFINS. HOMA-IRN LHT was negatively correlated. Multiple linear regression analysis showed that HOMA-IRN LH. Conclusion the Nesfatin-1 level of newly diagnosed PCOS patients is lower than that of newly diagnosed PCOS patients. Nesfatin-1 may be involved in the occurrence and development of PCOS.
【作者单位】：南昌大学第一附属医院内分泌科;
【分类号】：R711.75
【正文快照】： 多囊卵巢综合征(polycystic ovary syndrome,PCOS)是青春期和育龄期女性常见的生殖内分泌紊乱性疾病,其发生率占育龄期女性的5%~10%[1]。PCOS的主要特征是卵巢的多囊样改变、持续不排卵、雄激素过高和胰岛素抵抗,病因至今仍不明确。有研究认为遗传因素、下丘脑-垂体功能障碍、

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