宫颈癌患者术后旋转调强与固定野调强放疗计划的剂量学比较

发布时间：2018-01-15 00:09

本文关键词：宫颈癌患者术后旋转调强与固定野调强放疗计划的剂量学比较　出处：《吉林大学学报(医学版)》2015年04期 　论文类型：期刊论文

【摘要】：目的:探讨宫颈癌患者术后放疗旋转调强放射治疗(IMAT)和固定野调强放射治疗(IMRT)剂量学的优劣,为其临床应用提供依据。方法:选择宫颈癌根治术后患者19例,行CT模拟定位,并勾画靶区及危及器官。在Eclipse 8.6计划系统上分别对每例患者设计IMAT和IMRT 2种放疗计划,评估靶区及危及器官的剂量学差异。结果:19例患者IMAT和IMRT放疗计划的设计时间分别为(129±3)和(30±1)min(P=0.000),在Varian IX加速器上的治疗时间分别为(3.17±0.23)和(6.55±0.17)min(P=0.009),靶区均匀指数(HI)分别为1.08±0.01和1.10±0.01(P=0.175),靶区适形指数(CI)分别为0.88±0.01和0.82±0.01(P=0.000)。IMRT计划的直肠、膀胱、小肠和股骨颈等危及器官受量接近或略小于IMAT。结论:与IMRT相比,IMAT在靶区剂量和CI有一定的优势,HI和危及器官受量两者较为接近,IMAT计划设计耗时增加了近3倍,治疗时间减少一半。临床上在计划设计时间充裕的前提下,建议尽量设计IMAT计划。
[Abstract]:Objective: to investigate the dosimetry of IMATT and IMRTT in patients with cervical cancer after radiotherapy with rotational intensity modulated radiotherapy (IMATT) and fixed field intensity modulated radiotherapy (IMRT). Methods: 19 cases of cervical cancer after radical resection were selected and CT imitated localization was performed. At the same time, the target area and the organs at risk were delineated. The IMAT and IMRT radiotherapy plans were designed for each patient on the Eclipse 8.6 planning system, respectively. Results the design time of IMAT and IMRT was 129 卤3 and 30 卤1 min respectively in 19 patients with 1: 19. P0. 000). The time of treatment on Varian IX accelerator was 3.17 卤0.23) and 6.55 卤0.17 min / min respectively. The target area uniformity index (HI) was 1.08 卤0.01 and 1.10 卤0.01 respectively. The target area conformal index (CI) was 0.88 卤0.01 and 0.82 卤0.01 respectively. IMRT was planned for rectum and bladder. Conclusion: compared with IMRT, IMAT has some advantages over IMRT in target dose and CI. The design time of the IMAT plan has increased nearly threefold and the treatment time has been reduced by half. It is recommended that the IMAT plan be designed as much as possible clinically if there is plenty of time for the plan design.
【作者单位】：重庆市肿瘤研究所资产设备部;吉林大学第一医院放疗科;重庆市肿瘤研究所妇瘤科;重庆市肿瘤研究所放疗科;
【基金】：重庆市卫生计生委医学科研计划项目资助课题(20140293)
【分类号】：R737.33
【正文快照】： 近年来,随着计算机技术、CT技术和直线加速器的发展及多叶光栅技术的日益完善,很多放疗新技术已经开始在临床上广泛使用。固定野调强放疗(intensity-modulated radiation therapy,IMRT)技术已经广泛应用于宫颈癌术后放疗,其可以提高靶区适形度,减少周围正常器官的受量。旋转调

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