蛋白酪氨酸磷酸酶1B在子宫内膜癌中的表达

发布时间：2018-01-15 18:03

本文关键词：蛋白酪氨酸磷酸酶1B在子宫内膜癌中的表达　出处：《现代预防医学》2015年06期 　论文类型：期刊论文

【摘要】：目的检测蛋白质酪氨酸磷酸酶1B(Protein Tyrosine Phosphatase 1B,PTP1B)在子宫内膜癌组织中的表达。方法随机选取2008.8-2009.12哈尔滨医科大学附属第二医院住院的新发子宫内膜癌患者30例和同期住院患者20例(子宫内膜组织11例和子宫内膜不典型增生组9例)分别设为实验组和对照组,通过免疫组化的方法检测PTP1B在各组织中的表达,统计阳性率,SPSS软件分析结果。结果免疫组织化学结果显示PTP1B在大多数子宫内膜癌组织中表达。PTP1B在子宫内膜癌中的阳性率明显高于对照组(P0.05),对照组中子宫内膜不典型增生组阳性率高于正常子宫内膜组中的阳性率,但差异无统计学意义(P0.05)。PTP1B在高分化内膜癌组织中阳性表达率明显低于在中低分化内膜癌组织中阳性表达率(P0.05),在子宫内膜癌合并糖尿病患者中的阳性率高于未合并糖尿病者(P0.05)。而在针对不同临床-病理分期(I期和II-IV)的阳性率比较,差异无统计学意义(P0.05)。结论 PTP1B的表达与子宫内膜组织的病变性质有关,为子宫内膜癌的预防和治疗提供新思路。
[Abstract]:Objective to detect the protein tyrosine phosphatase 1B protein Tyrosine Phosphatase 1B. PTP1B). Methods 30 newly diagnosed endometrial carcinoma patients hospitalized in the second affiliated Hospital of Harbin Medical University and 20 in-patients in the same period were randomly selected from 2008 to December 2009.2008.2008.2009.12. Example (. 11 cases of endometrial tissue and 9 cases of atypical hyperplasia of endometrium were divided into experimental group and control group. Immunohistochemical method was used to detect the expression of PTP1B in all tissues and the positive rate was counted. Results Immunohistochemical results showed that the positive rate of PTP1B expression in endometrial carcinoma was significantly higher than that in control group (P < 0.05). P0.05). The positive rate of endometrial atypical hyperplasia in control group was higher than that in normal endometrium group. However, there was no significant difference in the positive expression rate of P0.05N. PTP1B in well-differentiated endometrial carcinoma tissues, which was significantly lower than that in low-differentiated endometrial carcinoma tissues (P0.05). The positive rate in endometrial carcinoma patients with diabetes was higher than that in patients without diabetes mellitus (P 0.05), but the positive rates of stage I and II-IVfor different clinicopathological stages were compared. Conclusion the expression of PTP1B is related to the nature of endometrial lesions, which provides a new idea for the prevention and treatment of endometrial carcinoma.
【作者单位】：哈尔滨医科大学附属第五医院;大庆市人民医院;哈尔滨医科大学附属第二医院妇一病房;哈尔滨市第一医院妇产科;天津市第三中心医院妇产科;广东省广州市妇女儿童医疗中心妇产科;
【基金】：国家自然基金(面上项目,C140206)
【分类号】：R737.33
【正文快照】： 子宫内膜癌(Endometrial carcinoma)是妇科常见的恶性肿瘤之一,占女性生殖系统恶性肿瘤的20%~30%。近年来,发病率在世界范围内呈上升趋势,仅次于子宫颈癌,且生存率逐年下降[1]。但是发病机制还不清楚。肥胖、糖尿病、高血压及多囊卵巢综合症(Polycystic Ovarian Syndrome,PCOS

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