门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的疗效分析

发布时间：2018-01-15 17:33

  本文关键词：门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的疗效分析　出处：《中外医疗》2016年35期 　论文类型：期刊论文

  更多相关文章： 妊娠糖尿病 门冬胰岛素 地特胰岛素 临床效果

【摘要】：目的探讨门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的临床疗效。方法方便选择该院自2014年1月—2016年6月收治的74例妊娠糖尿病患者为研究对象,并按照随机数字表法分为对照组和观察组,每组各37例。对照组患者使用生物合成人胰岛素注射液治疗(三餐前30 min皮下注射),观察组患者接受门冬胰岛素(三餐前进食前皮下注射)+地特胰岛素(睡前皮下注射)治疗。比较两组患治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、血糖达标时间及低血糖发生率差异。结果治疗前两组间FBG[对照组和观察组分别为(9.57±3.24)mmol/L vs(9.54±2.68)mmol/L,t=0.526]、2 h PG[对照组和观察组分别为(15.43±3.58)mmol/L vs(15.54±2.52)mmol/L,t=-0.632]和Hb A1c[对照组和观察组分别为(10.54±1.25)%vs(10.48±1.32)%,t=0.695]差异无统计学意义(P0.05),治疗后两组FBG[对照组和观察组分别为(6.78±2.15)mmol/L vs(5.43±1.64)mmol/L,t=0.3.423]、2 h PG[对照组和观察组分别为(11.36±2.46)mmol/L vs(9.23±1.54)mmol/L,t=3.695]和Hb A1c[对照组和观察组分别为(7.65±1.54)%vs(6.23±1.63)%,t=3.452]较治疗前均明显降低,与治疗前相比差异无统计学意义(P0.05),且观察组患者较对照组下降更为明显(与对照组治疗后相比,P0.05)。治疗期间观察组患者血糖达标时间(6.24±1.43)d和低血糖发生率(5.41%)均明显低于对照组[分别为(8.56±2.14)d、(18.9%)]患者,差异有统计学意义(t=3.562,χ2=3.446,P0.05)。结论门冬胰岛素联合地特胰岛素治疗妊娠糖尿病临床效果显著,低血糖发生率低,值得在临床中推广应用。
[Abstract]:Objective to investigate the clinical efficacy of insulin aspart insulin detemir treatment of gestational diabetes mellitus. Methods to facilitate the selection of the hospital since January 2014 June 2016 were treated 74 cases of gestational diabetes patients as the research object, and randomly divided into control group and observation group, 37 cases in each group. The control group was treated with Biosynthetic Human Insulin Injection treatment (before meals 30 min subcutaneous injection), patients in the observation group received insulin aspart (meals intake before subcutaneous injection of insulin detemir (+) before subcutaneous injection) treatment. Compare the two groups before and after treatment with fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PG), glycosylated hemoglobin (Hb A1c), blood glucose time and hypoglycemia the incidence of the difference between the two groups before treatment. Results FBG[observation group and the control group respectively (9.57 + 3.24) mmol/L vs (9.54 + 2.68) mmol/L, t=0.526] 2, H PG [the observation group and the control group respectively (15. 43卤3.58)mmol/L vs(15.54卤2.52)mmol/L,t=-0.632]鍜孒b A1c[瀵圭収缁勫拰瑙傚療缁勫垎鍒�涓�(10.54卤1.25)%vs(10.48卤1.32)%,t=0.695]宸�寮傛棤缁熻�″�︽剰涔�(P0.05),娌荤枟鍚庝袱缁凢BG[瀵圭収缁勫拰瑙傚療缁勫垎鍒�涓�(6.78卤2.15)mmol/L vs(5.43卤1.64)mmol/L,t=0.3.423],2 h PG[瀵圭収缁勫拰瑙傚療缁勫垎鍒�涓�(11.36卤2.46)mmol/L vs(9.23卤1.54)mmol/L,t=3.695]鍜孒b A1c[瀵圭収缁勫拰瑙傚療缁勫垎鍒�涓�(7.65卤1.54)%vs(6.23卤1.63)%,t=3.452]杈冩不鐤楀墠鍧囨槑鏄鹃檷浣，

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