ERα、EGFR及CyclinD1在上皮性卵巢癌中的表达及意义

发布时间：2018-01-15 18:44

本文关键词：ERα、EGFR及CyclinD1在上皮性卵巢癌中的表达及意义　出处：《山东医药》2014年29期 　论文类型：期刊论文

【摘要】：目的探讨雌激素受体α(ERα)、表皮生长因子受体(EGFR)及细胞周期蛋白D1(CyclinD1)在上皮性卵巢癌中的表达及临床意义。方法采用免疫组化SP法观察ERα、EGFR及CyclinD1在上皮性卵巢癌组织58份(浆液性卵巢癌组织38份、非浆液性卵巢癌组织20份)、正常卵巢组织18份、卵巢良性肿瘤组织20份中的表达情况。结果 ERα、EGFR及CyclinD1在上皮性卵巢癌组织中的阳性表达率分别为74.13%、68.97%、51.72%,显著高于正常卵巢组织(33.33%、16.67%、0)及卵巢良性肿瘤组织(30.0%、25.0%、10.0%)(P均0.05);但ERα、EGFR及CyclinD1在卵巢良性肿瘤、正常卵巢组织中的阳性表达率比较P均0.05。ERα、EGFR及CyclinD1在上皮性卵巢癌中的表达与临床分期及细胞分化程度有关(P均0.05)。结论 ERα、EGFR及CyclinD1在上皮性卵巢癌中过表达,并在一定程度上反映其恶性程度及预后状况。
[Abstract]:Objective to study the estrogen receptor 伪 (ER 伪). The expression and clinical significance of epidermal growth factor receptor (EGFR) and cyclin D _ (1) in epithelial ovarian carcinoma were observed by immunohistochemical SP method. EGFR and CyclinD1 were detected in 58 cases of epithelial ovarian carcinoma (38 cases of serous ovarian cancer, 20 cases of non-serous ovarian cancer and 18 cases of normal ovarian tissue). Results the positive rates of ER 伪 -EGFR and CyclinD1 in epithelial ovarian carcinoma were 74.13%, respectively. 68.97 and 51.72% were significantly higher than those in normal ovarian tissue (33.33%) and benign ovarian tumor tissue (30.0%, 25.0%). 0. 0%, 0. 05% and 0. 05%. But the positive expression rates of ER 伪 EGFR and CyclinD1 in benign ovarian tumors and normal ovarian tissues were both P 0.05. The expression of EGFR and CyclinD1 in epithelial ovarian carcinoma is related to clinical stage and cell differentiation degree (P 0.05). Conclusion ER 伪 is related to the expression of EGFR and CyclinD1 in epithelial ovarian carcinoma. The overexpression of EGFR and CyclinD1 in epithelial ovarian carcinoma reflects the malignant degree and prognosis to some extent.
【作者单位】：青岛大学附属医院;费县人民医院;
【分类号】：R737.31
【正文快照】： 上皮性卵巢癌是常见的卵巢肿瘤,约占卵巢原发性恶性肿瘤的85%~90%[1]。由于缺乏有效的早期诊断方法,75%的患者就诊时已是晚期,故其病死率较高[2]。目前,上皮性卵巢癌的发病机制还不十分清楚,可能是多因素共同作用的结果。2008~2012年,我们观察了雌激素受体α(ERα)、表皮生长

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