子宫颈癌发生发展中HLA基因易感及NK细胞受体免疫应答的作用

发布时间：2018-01-16 11:53

本文关键词：子宫颈癌发生发展中HLA基因易感及NK细胞受体免疫应答的作用　出处：《中国免疫学杂志》2015年11期 　论文类型：期刊论文

【摘要】：目的:探究子宫颈癌发生发展中HLA基因易感及NK细胞受体免疫应答的作用。方法:本研究选取2013年1月至2014年1月于我院诊治,并经病理活检证实为子宫颈癌的患者200例作为观察组,同时,随机选取200例健康妇女为对照组。两组均在入院时取外周血2 ml,采集观察组的宫颈细胞样品用来进行细胞学观察和HPV的DNA探查,观察两组人员HPV感染率和HLA分型。结果:两组入组人员HPV感染阳性率分别为91%、16%,两组比较,差异具有统计学意义(P0.05)。观察组患者HLA-KIR*1003、HLA-KIR*14、HLA-KIR*17、HLA-KIR*02、HLA-KIR*12的分布频率分别为41%、39%、35%、15%、53%,对照组分别为18%、15%、14%、52%、89%,两组比较差异均具有统计学意义(P0.05),其中观察组患者HLA-KIR*1003、HLA-KIR*14、HLA-KIR*17分布频率明显高于对照组,HLA-KIR*02、HLA-KIR*12的分布频率明显低于对照组。结论:在子宫颈癌发生发展的过程中,存在HLA-KIR*1003、HLA-KIR*14、HLA-KIR*17等位基因易感,而HLAKIR*02、HLA-KIR*12等位基因可减少宫颈癌的发生。
[Abstract]:Objective: to investigate the role of HLA gene susceptibility and NK cell receptor immune response in the occurrence and development of cervical cancer. Methods: from January 2013 to January 2014, the study was conducted in our hospital. 200 cases of cervical cancer confirmed by pathological biopsy as the observation group, and 200 healthy women as the control group were randomly selected. The peripheral blood of both groups were taken 2 ml on admission. Samples of cervical cells were collected from the observation group for cytological observation and DNA detection of HPV. HPV infection rate and HLA typing were observed in two groups. Results: the positive rates of HPV infection in the two groups were 91% and 16%, respectively. The difference was statistically significant (P 0.05). The distribution frequency of HLA-KIR*12 was 41% and 39%, respectively. In the control group, it was 18% and 52%, respectively. The difference between the two groups was statistically significant (P 0.05), among which HLA-KIRN 1003T HLA-KIR14 was found in the observation group. The frequency of HLA-KIR*17 distribution was significantly higher than that of control group. The distribution frequency of HLA-KIR*12 was significantly lower than that of the control group. Conclusion: during the development of cervical cancer, there is HLA-KIR1 003 HLA-KIR14. HLA-KIR*17 alleles were susceptible, while HLA-KIR12 alleles were associated with a decrease in the occurrence of cervical cancer.
【作者单位】：广州医科大学附属第三医院生殖中心;广州医科大学附属第三医院妇科;
【基金】：广东省医学科学技术研究基金(WSTJJ20121108440102197212313220)资助
【分类号】：R737.33
【正文快照】： 1本文受广东省医学科学技术研究基金(WSTJJ20121108440102197212313220)资助。2广州医科大学附属第三医院妇科,广州510510。子宫颈癌是较为常见的女性恶性肿瘤,其发病率仅次于乳腺癌,其中发展中国家发病率较高,有资料显示,大于85%的子宫颈癌新发及死亡病例在发展中国家,其中印

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