疏肝益肾汤联合枸橼酸氯米芬治疗无排卵性不孕症45例

发布时间：2018-01-17 14:13

本文关键词：疏肝益肾汤联合枸橼酸氯米芬治疗无排卵性不孕症45例　出处：《中国实验方剂学杂志》2015年14期 　论文类型：期刊论文

【摘要】：目的:探讨疏肝益肾汤联合枸橼酸氯米芬治疗无排卵性不孕症的临床疗效及对性激素的影响。方法:90例无排卵性不孕症就诊患者采用随机按数字表法分为治疗组和对照组各45例。治疗组给予疏肝益肾汤联合枸橼酸氯米芬治疗;对照组给予枸橼酸氯米芬治疗。两组疗程均为3个月经周期。采用B超监测卵泡发育情况,统计排卵率、妊娠率和流产率;酶联免疫法测定血清睾酮(T),泌乳素(PRL),促黄体生成素(LH),雌二醇(E2),卵泡刺激素(FSH)的水平。结果:治疗后治疗组的排卵率、妊娠率高于对照组(P0.05),流产率低于对照组(P0.05);治疗后治疗组的月经不调例数低于对照组(P0.05),月经量少、色黯例数低于对照组(P0.01);治疗后治疗组的患者子宫内膜厚度显著高于对照组(P0.05);治疗后治疗组的睾酮、泌乳素、黄体生成素和卵泡刺激素水平低于对照组(P0.05);两组雌二醇水平均降低,组间差异无统计学意义。结论:疏肝益肾汤联合枸橼酸氯米芬可温肾助阳,疏肝调经,能提高无排卵性不孕症患者的妊娠率,临床疗效优于单纯的枸橼酸氯米芬治疗。
[Abstract]:Objective: to investigate the clinical effect of Shugan Yishen decoction combined with clomiphene citrate in the treatment of anovulation infertility. Ninety patients with anovulation infertility were randomly divided into treatment group (n = 45) and control group (n = 45). The treatment group was treated with Shugan Yishen decoction combined with clomiphene citrate. The control group was treated with clomiphene citrate. The two groups were treated for 3 menstrual cycles. B ultrasound was used to monitor follicle development, and the ovulation rate, pregnancy rate and abortion rate were counted. Serum testosterone, prolactin, luteinizing hormone and estradiol E _ 2 were determined by enzyme-linked immunosorbent assay (Elisa). Results: after treatment, the ovulation rate and pregnancy rate in the treatment group were higher than those in the control group (P 0.05), and the abortion rate was lower than that in the control group (P 0.05). After treatment, the number of menstrual irregularities in the treatment group was lower than that in the control group (P 0.05), the menstrual volume was less, and the number of color dark cases was lower than that in the control group (P 0.01). The endometrial thickness in the treatment group was significantly higher than that in the control group (P 0.05). After treatment, the levels of testosterone, prolactin, luteinizing hormone and follicle stimulating hormone in the treatment group were lower than those in the control group (P 0.05). Conclusion: Shugan Yishen decoction combined with clomiphene citrate can warm the kidney to help the yang, soothe the liver and regulate the menstruation, can improve the pregnancy rate of the patients with anovulation infertility. The clinical efficacy is superior to that of clomiphene citrate alone.
【作者单位】：北京军区总医院二六三临床部;中国人民解放军总参谋部总医院;
【分类号】：R711.6
【正文快照】： 女性不孕症是妇科常见疑难病之一,是指夫妻双方未采取任何避孕措施,正常同居2年,排除男方异常,或曾怀孕未避孕2年以上未孕的病理现象[1]。资料统计显示[2],无排卵是不孕的主要原因,占26%。无排卵对女性的影响除不孕症外,还可出现子宫出血、闭经、肥胖等症状,长期发展会导致子

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