血清HE4、CA125、VEGF联合检测对卵巢癌诊断价值分析

发布时间：2018-01-18 05:34

本文关键词：血清HE4、CA125、VEGF联合检测对卵巢癌诊断价值分析　出处：《医学研究杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的探讨血清人附睾蛋白4(HE4)、癌抗原-125(CA125)、血管表皮生长因子(VEGF)联合检测对卵巢癌诊断价值,为临床诊断提供一定的参考价值。方法本研究病例来源于2013年5月~2015年5月期间笔者医院收治的107例卵巢疾病患者,按照术后病理结果将其分为卵巢癌组43例与良性病变组64例。选择同期于笔者医院体检中心体检的健康女性50例作为健康对照组。检测各组血清HE4、CA125、VEGF水平变化及联合检测敏感度和特异性。结果卵巢癌组和卵巢良性病变组血清HE4水平明显高于健康对照组(P0.05);卵巢癌组血清HE4水平明显高于卵巢良性病变组(P0.05);卵巢癌组和卵巢良性病变组血清CA125水平明显高于健康对照组(P0.05);卵巢癌组血清CA125水平明显高于卵巢良性病变组(P0.05);卵巢癌组和卵巢良性病变组血清VEGF水平明显高于健康对照组(P0.05);卵巢癌组血清VEGF水平明显高于卵巢良性病变组(D0.05);血清HE4+CA125+VEGF联合检测敏感度和特异性明显高于单检测血清HE4、CA125、VEGF(P0.05)。结论血清HE4、CA125、VEGF在卯巢癌患者中呈高表达,3种肿瘤标志物联合检测具有着较高的敏感度和特异性,可作为诊断卵巢癌的重要手段,具有重要研究价值。
[Abstract]:Objective to evaluate the diagnostic value of serum human epididymal protein (Hepididymal protein 4), carcinoantigen 125 (CA125) and vascular epidermal growth factor (VEGF) in the diagnosis of ovarian cancer. Methods from May 2013 to May 2015, 107 patients with ovarian diseases were treated in our hospital. According to the postoperative pathological results, it was divided into ovarian cancer group (43 cases) and benign disease group (64 cases). 50 healthy women who were examined in our hospital physical examination center at the same time were selected as healthy control group. Serum HE4 was detected in each group. Results the serum HE4 level in ovarian cancer group and benign ovarian disease group was significantly higher than that in healthy control group (P 0.05). The serum HE4 level in ovarian cancer group was significantly higher than that in benign ovarian disease group (P 0.05). Serum CA125 levels in ovarian cancer group and benign ovarian disease group were significantly higher than those in healthy control group (P 0.05). The serum CA125 level in ovarian cancer group was significantly higher than that in benign ovarian disease group (P 0.05). Serum VEGF levels in ovarian cancer group and benign ovarian disease group were significantly higher than those in healthy control group (P 0.05). The serum VEGF level in ovarian cancer group was significantly higher than that in benign ovarian disease group. The sensitivity and specificity of combined detection of serum HE4 CA125 VEGF were significantly higher than that of serum HE4, CA125 and VEGF P0.05.Conclusion Serum HE4. The combined detection of VEGF with high expression of CA125 and VEGF has high sensitivity and specificity, and can be used as an important method in the diagnosis of ovarian cancer and has important research value.
【作者单位】：金华市人民医院妇产科;
【分类号】：R737.31
【正文快照】： 流行病学调查研究发现,卵巢癌发生率位居女性生殖系统肿瘤第3位,仅次于子宫颈癌和子宫体癌,但该病却为妇科疾病中预后最差的一种恶性肿瘤,严重威胁患者生命:1]。目前,对于卵巢癌发病机制尚不十分清楚,可能与年龄、环境、血型、生育以及精神因素等相关m。大部分卵巢癌患者就

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