不同促排卵与激素替代治疗方案对人种植窗期子宫内膜LIF、IL-1β与整合素αVβ3表达的影响

发布时间：2018-01-18 06:06

本文关键词：不同促排卵与激素替代治疗方案对人种植窗期子宫内膜LIF、IL-1β与整合素αVβ3表达的影响　出处：《郑州大学学报(医学版)》2017年05期 　论文类型：期刊论文

【摘要】：目的:探讨诱发排卵、控制性超促排卵(COH)、激素替代治疗(HRT)方案对人种植窗期子宫内膜容受性的影响。方法:选取60例取消移植的患者作为研究对象。20例为自然周期排卵,10例为诱发排卵,20例为COH方案,10例采用HRT方案。每个方案分别于排卵后第5、6天(D5、D6)采集半数研究对象的内膜,免疫组化SP法检测LIF、IL-1β与整合素αVβ3蛋白的表达。结果:相同方案的D5与D6内膜间比较,3种蛋白的表达量差异均无统计学意义(P0.05)。诱发排卵组、COH组、HRT组3种蛋白在内膜中的相对表达量均低于自然周期组,其中诱发排卵组最低,HRT组高于COH组(P0.05)。结论:HRT方案对人种植窗期子宫内膜容受性的影响最小。
[Abstract]:Objective: to investigate the induction of ovulation and control hyperstimulation of ovulation (COH). Effects of hormone replacement therapy (HRT) regimen on endometrial receptivity during implantation window phase. Methods: 60 patients with cancellous transplantation were selected as study subjects. 20 patients were ovulated in natural cycle. Ten cases were induced ovulation. 20 cases were COH regimen. 10 cases were treated with HRT regimen. The intima of half of the subjects were collected from each scheme on the 6th day after ovulation. Immunohistochemical SP method was used to detect the expression of IL-1 尾 and integrin 伪 V 尾 3. Results: D5 and D6 of the same regimen were compared. There was no significant difference in the expression of the three proteins among the three proteins. The relative expression of the three proteins in the endometrium of the COH group was lower than that of the natural cycle group. Among them, the lowest induced ovulation group was higher than the COH group P0.050.Conclusion the effect of the 10% HRT regimen on the endometrial receptivity of human implantation window is the least.
【作者单位】：郑州大学第二附属医院生殖中心;
【基金】：河南省教育厅科技攻关项目142300410240
【分类号】：R714.8
【正文快照】： △女,1964年4月生,博士,主任医师,教授,研究方向:辅助生殖技术与生殖内分泌,E-mail:litan668@126.comTAN Li,LIU Xinyuan,CHU Xiying,LU Na,XIANG Yungai,SONG Yuxia,LI PengfenReproductive Center,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014辅

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