激素替代治疗改善绝经期妇女生存质量的效果评价研究

发布时间：2018-01-19 07:00

本文关键词： 激素替代治疗绝经期妇女生存质量　出处：《中国药学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的评价激素替代治疗(HRT)对绝经期妇女生存质量的影响。方法收集北京妇产医院门诊就诊的绝经期妇女202例,分为未行HRT组(1组),首次HRT组(2组),已行HRT组(3组),跟踪随访1年,每3个月随访1次,由专人评估患者的改良Kupperman评分(改良KI)、绝经期生存质量量表(MENQOL)、焦虑自评量表(SAS)和抑郁自评量表(SDS),并对患者进行生活方式的指导。结果三组患者一年后改良KI、MENQOL、SAS的评分值有显著改善(P=0.003,0.007,0.014),且改良KI、MENQOL出现显著性改善的时间早于SAS;SDS的评分值虽有改善,但无显著性变化(P=0.109)。1组患者各量表评分有显著改善,但改善程度弱于2、3组。HRT与各量表的评分值呈负相关,文化程度与SAS、SDS的评分值呈正相关。结论 HRT能够改善患者的生存质量,且对躯体症状的改善早于精神症状。文化程度高的绝经期患者更易发生焦虑和抑郁。传统中医药、运动疗法和物理康复可作为辅助治疗手段用于不能或不愿接受HRT的患者。
[Abstract]:Objective to evaluate the effect of hormone replacement therapy (HRT) on the quality of life of menopausal women. Methods 202 postmenopausal women in Beijing Obstetrics and Obstetrics Hospital were divided into 2 groups without HRT. The patients in the first HRT group were followed up for 1 year, followed up once every 3 months. The modified Kupperman score (modified Ki) of the patients was evaluated by special person. The menopausal quality of life scale (MENQOLA), Self-Rating anxiety scale (SAS) and Self-Rating Depression scale (SDS) were used to guide the patients' lifestyle. Results Ki was improved in the three groups after one year. The score of MENQOLN SAS was significantly improved, and the time of significant improvement of modified KI MENQOL was earlier than that of SAS. Although the score of SDS was improved, there was no significant change. The scores of each scale were significantly improved, but the degree of improvement was weaker than that of 2. There was a negative correlation between HRT and the score of each scale, and a positive correlation between the education level and the score of SSAS-SDS. Conclusion HRT can improve the quality of life of the patients. The improvement of somatic symptoms is earlier than that of mental symptoms. Menopausal patients with high education level are more likely to develop anxiety and depression. Traditional Chinese medicine. Exercise therapy and physical rehabilitation can be used as adjuvant therapy for patients who are unable or unwilling to accept HRT.
【作者单位】：首都医科大学附属北京妇产医院科技处;首都医科大学附属北京妇产医院内分泌科;首都医科大学卫生管理与教育学院;
【基金】：首都医科大学基础-临床科研合作基金资助项目
【分类号】：R711.75
【正文快照】： 妇女在绝经前后由于卵巢功能的衰退,雌激素水平明显下降,出现以植物神经系统功能紊乱为主伴有精神心理症状的一组症候群,包括血管疏缩症状、骨质疏松症状、泌尿生殖道萎缩、自主神经失调和情绪障碍等,从而影响到女性的生存质量。随着生活水平的提高和妇女寿命的延长,绝经前后

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