宫颈锥形切除术后宫颈组织中TNF-α、IL-6、HMGB1的表达及其意义研究

发布时间：2018-01-19 12:36

本文关键词： 子宫颈锥形切除术后子宫切除术肿瘤坏死因子α 白细胞介素高迁移率族蛋白质类术后感染　出处：《重庆医学》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨宫颈锥形切除术后宫颈分泌物及宫颈组织中炎性因子的动态变化及其意义。方法选取2013-2015年在该院就诊的行宫颈锥形切除术患者,术后定期采集宫颈创面分泌物及周围组织,定量检测肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、高迁移率族蛋白1(HMGB1)的表达,以术前作为对照组,进行统计分析。观察宫颈锥形切除术后行全子宫切除的标本中炎性细胞的浸润及表达。结果宫颈组织及分泌物中TNF-α、IL-6、HMGB1的表达在宫颈锥形切除术后逐渐升高,术后1~2周达到高峰,与术前比较差异有统计学意义(P0.05),之后逐渐下降。在宫颈锥形切除术后1周行全子宫切除的标本病理显示,炎性细胞浸润及炎症反应最严重;其TNF-α、IL-6及HMGB1表达较术后4周明显升高。结论宫颈锥形切除术后1~2周时宫颈创面炎症最为严重,应避免在此阶段行全子宫切除。
[Abstract]:Objective to investigate the dynamic changes and significance of inflammatory factors in cervical secretions and cervical tissues after cervical conical resection. The secretion of cervical wound and its surrounding tissues were collected regularly after operation, and tumor necrosis factor- 伪 (TNF- 伪) and interleukin-6 (IL-6) were detected quantitatively. The expression of high mobility group protein 1 (HMGB1) was preoperatively used as the control group. To observe the infiltration and expression of inflammatory cells in the specimens after total hysterectomy. Results TNF- 伪 IL-6 was found in cervical tissues and secretions. The expression of HMGB1 increased gradually after cervical conical resection and reached its peak at 1 and 2 weeks postoperatively (P 0.05). The pathological results showed that inflammatory cell infiltration and inflammatory reaction were the most serious in the specimens with total hysterectomy 1 week after cervical conical resection. The expression of TNF- 伪 IL-6 and HMGB1 was significantly higher than that at 4 weeks after operation. Conclusion the inflammation of cervix wound is the most serious at 1 ~ 2 weeks after conical resection of cervix, and total hysterectomy should be avoided at this stage.
【作者单位】：江苏大学第四附属医院暨镇江市妇幼保健院妇科;
【基金】：国家自然科学基金项目(81402165,81672913) 江苏省自然科学基金项目(BK20141288) 江苏省镇江市科技支撑计划-社会发展基金资助项目(SH2013088)
【分类号】：R737.33
【正文快照】： 在宫颈上皮内瘤变Ⅲ级和子宫颈浸润癌Ⅰa1期患者的处理过程中,宫颈锥形切除术是其诊断和治疗的重要环节。接受宫颈锥形切除术的部分患者中后续需行全子宫切除术。本文连续检测宫颈锥形切除术后宫颈组织及分泌物中肿瘤坏死因子-α(tumornecrosis factor-a,TNF-α)、白细胞介素-

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