重组人干扰素α-2b治疗宫颈糜烂合并人乳头瘤病毒感染的临床观察

发布时间：2018-01-19 13:08

本文关键词： 重组人干扰素α-b 宫颈糜烂人乳头瘤病毒疗效安全性特异性转录因子炎症因子　出处：《中国药房》2017年03期 　论文类型：期刊论文

【摘要】：目的:观察重组人干扰素α-2b治疗宫颈糜烂合并人乳头瘤病毒(HPV)感染的疗效和安全性。方法:81例宫颈糜烂合并HPV感染患者随机分为对照组(40例)和观察组(41例)。两组患者均于月经干净后3~7 d行微波治疗,微波治疗后3 d,对照组患者给予保妇康栓剂1粒,睡前置于阴道深部,每日1次,连用14 d。观察组患者在对照组治疗的基础上给予重组人干扰素α-2b凝胶1 g,每日1次,连用14 d。观察两组患者的临床疗效,HPV转阴率,治疗前后特异性转录因子(T-bet、GATA3、T-bet/GATA3、Fox P3)水平、炎症因子[白细胞介素(IL)-2、γ干扰素(IFN)-γ、IL-4、IL-10、转化生长因子(TGF)-β1、IFN-γ/IL-4]水平及不良反应发生情况。结果:观察组患者总有效率、HPV转阴率均显著高于对照组,差异均有统计学意义(P0.05)。治疗后,两组患者T-bet、T-bet/GATA3、IL-2、IFN-γ、IFN-γ/IL-4水平均显著高于同组治疗前,且观察组显著高于对照组;两组患者GATA3、Fox P3、IL-4、IL-10、TGF-β_1水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:在常规治疗的基础上,重组人干扰素α-2b治疗宫颈糜烂合并HPV感染的疗效和安全性均较好,可提高HPV转阴率。
[Abstract]:Objective: to observe the therapeutic effect of recombinant human interferon 伪 -2b on cervical erosion with human papillomavirus (HPV). Methods 81 patients with cervical erosion and HPV infection were randomly divided into control group (n = 40) and observation group (n = 41). The patients in both groups were treated with microwave on the 7th day after menstruation. 3 days after microwave treatment, the patients in control group were given 1 capsule of Baofukang suppository, placed in the deep part of vagina before bedtime, once a day. The patients in the observation group were treated with recombinant human interferon 伪 -2b gel 1 g once a day for 14 days on the basis of treatment in the control group. The clinical efficacy of the two groups was observed. HPV negative conversion rate, specific transcription factor T-beta GATA3, T-bet/ GATA3 / Fox P3, inflammatory factors before and after treatment. [Interleukin-2, IFN- 纬, IL-10, TGF- 尾 1, TGF- 尾 1, TGF- 尾 1, TGF- 尾 1, TGF- 尾 1, TGF- 尾 1, TGF- 尾 1. Results: the total effective rate of the observation group was significantly higher than that of the control group. The difference was statistically significant (P 0.05). After treatment, two groups of patients were treated with T-beton T-beta / GATA3- IL-2IFN- 纬. The level of IFN- 纬 / IL-4 was significantly higher than that of the control group before treatment, and that of the observation group was significantly higher than that of the control group. The levels of IL-10 TGF- 尾 1 in both groups were significantly lower than those in the same group before treatment, and those in the observation group were significantly lower than those in the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: on the basis of routine treatment, there is no significant difference in the incidence of adverse reactions between the two groups. The efficacy and safety of recombinant human interferon 伪 -2b in the treatment of cervical erosion with HPV infection were better, and the negative rate of HPV could be increased.
【作者单位】：重庆市开州区人民医院妇科;
【分类号】：R711.32
【正文快照】： 宫颈糜烂是妇科常见慢性炎症,严重者可发展为宫颈上皮内瘤变或癌症。人乳头瘤病毒(Human papilloma virus,HPV)是促进宫颈糜烂发生与发展的一个重要诱因。据悉,70%以上的宫颈糜烂患者能够依靠自身的免疫系统清除HPV,少数患者由于感染持续存在,很容易进入“宫颈炎-上皮内瘤变

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