冷冻胚胎-解冻移植术周期中子宫内膜微刺激效果评价

发布时间：2018-01-20 08:19

本文关键词： 冻融胚胎移植子宫内膜内膜微刺激术　出处：《中国实用妇科与产科杂志》2015年11期 　论文类型：期刊论文

【摘要】：目的探讨在冷冻胚胎-解冻移植(冻融胚胎移植,FET)周期中,子宫内膜微刺激术对自然周期患者子宫内膜评价指标及临床妊娠率的影响。方法 2013年1-7月于兰州大学第一医院生殖医学研究中心,前瞻性观察自然周期法实施冷冻胚胎-解冻移植术的不孕症患者591例,采用随机数字表法,将同期符合纳入标准行FET术的患者随机分为两组,分别为内膜刺激组与对照组,其中211例行内膜微刺激术(内膜刺激组),380例为对照组,对比不同时间和次数内膜微刺激对内膜形态特征的改善,分析微刺激术对FET周期治疗结局的影响。结果内膜微刺激术后超声监测HCG日两组子宫内膜厚度差异无统计学意义(P0.05);与对照组相比,内膜刺激组临床妊娠率差异无统计学意义(P0.05)。月经期和黄体期行内膜微刺激术两组临床妊娠率分别为60.00%和64.29%(P0.05);治疗前周期和第二周期移植妊娠率差异均无统计学意义(56.67%vs.60.00%,P0.05);第1次和第2次行内膜微刺激术后妊娠率为56.67%vs.54.17%(P0.05)。结论自然周期阴道超声监测子宫内膜提示形态较差的患者经内膜微刺激后可显著改善子宫内膜条件。内膜形态为C型的患者经微刺激后转为A型,可获得与对照组相同的妊娠率。
[Abstract]:Objective to investigate the cycle of frozen embryo thawed transfer (frozen-thawed embryo transfer). Effects of endometrial microstimulation on endometrial evaluation and clinical pregnancy rate in patients with natural cycle. Methods from January to July, 2013, Reproductive Medicine Research Center, first Hospital of Lanzhou University. A prospective study was made on 591 infertile patients undergoing cryopreservation and thawing transplantation by natural cycle method. The patients who met the standard of FET were randomly divided into two groups by random digital table. There were 211 cases of endometrial microstimulation (380 cases of endometrial stimulation group as control group). The morphological characteristics of endometrium were improved by different time and times of intimal microstimulation. Results there was no significant difference in endometrial thickness between the two groups on the day of HCG monitoring by ultrasound on the day of microstimulation, and there was no significant difference in endometrial thickness between the two groups (P 0.05). Compared with the control group. There was no significant difference in clinical pregnancy rate between endometrial stimulation group and luteal phase group (P 0.05). The clinical pregnancy rates were 60.00% and 64.29 in menstrual period and luteal phase respectively. ; There was no significant difference in the pregnancy rate between the second cycle and the second cycle before treatment. There was no significant difference in the pregnancy rate between the two groups (56.67vs.60.00) (P0.05). The pregnancy rate after the first and second endometrial microstimulation was 56.67vs.54.17 (P0.05). Conclusion the condition of endometrium can be improved significantly by natural cycle vaginal ultrasound in patients with poor endometrial morphology after microstimulation, and the patients with type C endometrium can change to type A after micro-stimulation. [WT5HZ] [WT5 "BZ] [WT5" BZ] [WT5 "HZ]. The pregnancy rate was the same as that in the control group.
【作者单位】：兰州大学第一医院生殖医学专科医院;
【分类号】：R714.8
【正文快照】： 体外受精-胚胎移植(IVF-ET)技术发展至今,促排卵刺激方案及实验室技术的长足进步使移植胚胎的质量有了明显提高,但种植率及最终的妊娠率仍不理想。慢性盆腔炎、宫内节育器、流产和分娩等造成的宫腔感染病因持续存在可形成慢性子宫内膜炎,导致子宫内膜修复障碍,使内膜容受性

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