青海地区子痫前期与可溶性人类白细胞相关抗原G和脐动脉血流动力学相关性研究

发布时间：2018-01-20 16:09

本文关键词： 先兆子痫 HLA抗原脐动脉青海　出处：《中国全科医学》2015年26期 　论文类型：期刊论文

【摘要】：目的检测青海地区子痫前期患者可溶性人类白细胞相关抗原G(s HLA-G)蛋白水平及脐动脉血流动力学指标,分析其间的相关性。方法选取2014年9—12月在青海大学附属医院分娩的产妇90例,其中正常妊娠妇女30例,轻度子痫前期患者26例,重度子痫前期患者34例。于临产前抽取3组研究对象静脉血,采用酶联免疫吸附试验(ELISA)检测s HLA-G水平;并采用多普勒超声诊断仪,检测脐动脉血流搏动指数(PI)、脐动脉血流阻力指数(RI)以及脐动脉收缩末期最大血流速度与舒张末期最大血流速度的比值(S/D)。结果 3组血清s HLA-G水平、PI、RI及S/D比较,差异均有统计学意义(P0.001);其中轻度子痫组和重度子痫组血清s HLA-G水平低于正常妊娠组,PI、RI及S/D均高于正常妊娠组;重度子痫组血清s HLA-G水平低于轻度子痫组,PI、RI及S/D均高于轻度子痫组,差异有统计学意义(P0.05)。3组尿蛋白值分布比较,差异有统计学意义(U=80.416,P0.05)。相关分析结果显示,子痫前期患者尿蛋白与血清s HLA-G呈负相关(r=-0.873,P0.05),s HLA-G与S/D呈负相关(r=-0.784,P0.05),s HLA-G与RI呈负相关(r=-0.522,P0.05),s HLA-G与PI呈负相关(r=-0.638,P0.05)。结论 s HLA-G蛋白水平和脐动脉血流动力学指标与子痫前期患者病情严重程度有关,且s HLA-G蛋白水平与脐动脉血流动力学存在相关性,测定SHLA-G和脐动脉血流动力学指标可预测胎儿宫内生长环境及出生结局。
[Abstract]:Objective to detect the level of soluble human leukocyte associated antigen (GnsHLA-G) protein and umbilical artery hemodynamics in preeclampsia patients in Qinghai province. Methods 90 cases of parturient delivered in the affiliated hospital of Qinghai University from September to December 2014 were selected. 30 cases of normal pregnant women and 26 cases of mild preeclampsia were selected. In 34 patients with severe preeclampsia, venous blood was collected from 3 groups of subjects before labor, and the level of s HLA-G was detected by Elisa. The umbilical artery pulsatility index (PII) was detected by Doppler ultrasound. Umbilical artery resistance index (RI) and the ratio of umbilical artery end systolic maximum velocity to end diastolic maximum flow velocity were compared. Results the serum s HLA-G level of the three groups was higher than that of the control group (P < 0. 05). The difference of RI and S / D was statistically significant (P 0.001). The levels of serum s HLA-G in mild eclampsia group and severe eclampsia group were lower than those in normal pregnancy group. The levels of serum s HLA-G in severe eclampsia group were lower than those in mild eclampsia group (P < 0.05). There was a significant difference between urine protein and serum s HLA-G in patients with preeclampsia (P 0.05). The correlation analysis showed that urine protein was negatively correlated with serum s HLA-G in patients with preeclampsia. There was a negative correlation between P0.05 HLA-G and S / D (r = -0.784). The correlation between HLA-G and RI was negative correlation (r ~ (0.05) -0.522 ~ (?) P _ (0.05)). S HLA-G and Pi were negatively correlated with r-0.638. Conclusion the levels of s HLA-G protein and umbilical artery hemodynamics are related to the severity of preeclampsia. The level of s HLA-G protein was correlated with umbilical artery hemodynamics. The measurement of SHLA-G and umbilical artery hemodynamic indexes could predict the fetal intrauterine growth environment and birth outcome.
【作者单位】：青海大学附属医院;
【基金】：青海省(应用)基础研究计划项目(2013-Z-736)
【分类号】：R714.244
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