p16INK4a蛋白在蒙古族患者宫颈病变组织中的表达及其意义

发布时间：2018-01-20 14:31

本文关键词： 宫颈肿瘤 INKa基因 pINKa蛋白宫颈上皮内瘤变慢性宫颈炎子宫平滑肌瘤　出处：《吉林大学学报(医学版)》2017年02期 　论文类型：期刊论文

【摘要】：目的:检测p16INK4a蛋白在蒙古族患者宫颈病变组织中的表达,探讨其与蒙古族患者宫颈癌发生发展的关系。方法:选取100例蒙古族患者宫颈癌、宫颈上皮内瘤变(CIN)、慢性宫颈炎和子宫平滑肌瘤病变组织石蜡切片,分为宫颈癌组25例、CIN组35例、慢性宫颈炎组20例和子宫平滑肌瘤组20例,利用免疫组织化学SP法检测各组石蜡切片组织中p16INK4a蛋白表达。结果:蒙古族患者宫颈癌、CIN、慢性宫颈炎、子宫平滑肌瘤组织中p16INK4a蛋白阳性表达率分别为100.0%、74.3%、25.0%和10.0%。多个样本比较的K-W H秩和检验,宫颈癌组p16INK4a蛋白阳性表达率高于CIN组、慢性宫颈炎组和子宫平滑肌瘤组(P0.05)。结论:p16INK4a蛋白可以作为筛选蒙古族早期宫颈癌患者的一种检测指标。
[Abstract]:Objective: to detect the expression of p16INK4a protein in cervical lesions of Mongolian patients, and to explore the relationship between p16INK4a protein and the occurrence and development of cervical cancer in Mongolian patients. Methods: 100 Mongolian patients with cervical cancer were selected. Cervical intraepithelial neoplasia (CINN), chronic cervicitis and uterine leiomyoma were divided into 25 cases of cervical carcinoma group and 35 cases of cin group. Immunohistochemical SP method was used to detect the expression of p16INK4a protein in paraffin sections of 20 patients with chronic cervicitis and 20 patients with uterine leiomyoma. The positive expression rates of p16INK4a protein in CIN, chronic cervicitis and uterine leiomyoma were 100.0% and 74.3%, respectively. The positive expression rate of p16INK4a protein in cervical cancer group was higher than that in CIN group. Conclusion the p16INK4a protein can be used as an index for screening early cervical cancer patients of Mongolian nationality.
【作者单位】：内蒙古民族大学人类基因组与遗传病研究所;内蒙古民族大学附属医院分子生物学实验室;
【基金】：内蒙古自治区科技厅科研基金资助课题(201502103)
【分类号】：R737.33
【正文快照】： 宫颈癌是目前妇科最常见的恶性肿瘤[1],其死亡率已占妇科肿瘤的首位[2]。宫颈癌发病率在世界范围内呈现年轻化和逐年上升的趋势,其病变的发生往往是从宫颈不典型增生→宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)→宫颈浸润癌由量变到质变、渐变到突变的连续发展

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