腰骶丛神经阻滞对家兔血清激素水平的影响

发布时间：2018-01-21 17:15

本文关键词：自主神经传导阻滞围绝经期雌激素类组织构建组织工程腰骶丛神经阻滞雌二醇促性腺激素释放激素卵泡刺激素黄体生成素围绝经期综合征自主神经　出处：《中国组织工程研究》2017年16期 　论文类型：期刊论文

【摘要】：背景:研究表明星状神经节阻滞可以改善围绝经期综合征中自主神经功能失调为基础引起的一系列症状,而腰骶丛神经阻滞与星状神经节阻滞一样,均属于自主神经阻滞,能发挥类似的作用。目的:针对自主神经中的腰骶丛进行阻滞干预,观察其对家兔血清激素及卵巢组织学的影响,希望能为临床围绝经期综合征的治疗提供新的治疗策略。方法:实验为随机对照动物实验,在中国贵阳,贵阳医学院动物实验中心完成。将健康家兔随机分为实验组和对照组,实验组腰大肌间沟推注阻断混合液进行腰骶丛神经阻滞阻断自主神经,对照组给予等量生理盐水。在家兔发情前、发情期及发情后观察腰骶丛神经阻滞对不同时期血清激素水平的影响(包括雌二醇、促性腺激素释放激素、卵泡刺激素和黄体生成素);在治疗一个完整发情周期后观察腰骶丛神经阻滞后卵巢的病理改变;在家兔经历了1,3及6个完整的发情周期后观察自主神经阻滞治疗的长短与激素的关系。实验过程遵循了国际兽医学编辑协会《关于动物伦理与福利的作者指南共识》和本地及国家法规,并遵守《动物实验体内实验研究报告规范指南》(ARRIVE指南)。结果与结论:腰骶丛神经阻滞可以增加血清雌激素水平,降低卵泡刺激素和黄体生成素水平,具有调节下丘脑垂体的功能,可以推测腰骶丛神经阻滞有可能用于围绝经期综合征的治疗或者辅助治疗,来缓解绝经期女性的不适症状。进一步实验应研究腰骶丛神经阻滞对去除卵巢家兔血激素的影响,判断是否对衰退卵巢有同样的干预效果。
[Abstract]:Background: studies have shown that stellate ganglion block can improve a series of symptoms based on autonomic dysfunction in peri-menopausal syndrome, while lumbosacral plexus block is the same as stellate ganglion block. Objective: to observe the effects of autonomic nerve block on serum hormones and ovarian histology in rabbits. We hope to provide a new strategy for the treatment of peri-menopausal syndrome. Methods: the experiment is a randomized controlled animal trial in Guiyang, China. The animal experimental center of Guiyang Medical College was completed. The healthy rabbits were randomly divided into two groups: the experimental group and the control group. The experimental group received lumbosacral plexus nerve block to block autonomic nerve. Before estrus, during estrus and after estrus, the effects of lumbosacral plexus nerve block on serum hormone level (including estradiol and gonadotropin releasing hormone) were observed in the control group. Follicle stimulating hormone and luteinizing hormone; The pathological changes of ovary after lumbosacral plexus nerve block were observed after a complete estrous cycle. The rabbits experienced 1. 3 and 6 complete estrous cycles to observe the relationship between the length of autonomic nerve block therapy and hormones. National laws and regulations. Results and conclusion: lumbosacral plexus nerve block can increase serum estrogen level. Reducing the levels of follicle stimulating hormone and luteinizing hormone has the function of regulating hypothalamic pituitary. It can be speculated that lumbosacral plexus nerve block may be used in the treatment of perimenopausal syndrome or adjuvant therapy. Further experiments should study the effect of lumbosacral plexus nerve block on the removal of serum hormone from ovarian rabbits and determine whether it has the same effect on ovarian recession.
【作者单位】：贵州省骨科医院妇产科;
【基金】：贵州省科技厅-贵州省人民医院联合基金项目(黔科合LS字[2012]052号)~~
【分类号】：R711.75
【正文快照】： 文章快速阅读:阻滞自主神经调节血清激素水平并改善卵巢病理变化实验组:卵巢病理改变进行腰骶丛神经阻滞阻断自主神经健康家兔·血清雌二醇(E2)对照组:·促性腺激素释放激素(GnR H)给予等量生理盐水·血清卵泡刺激素(FSH)·血清黄体生成素(LH)自主神经阻滞对不同时自主神经阻

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