卵巢上皮癌治疗前后血清CA125变化模式对判断预后和诊断复发的价值

发布时间：2018-01-22 09:49

  本文关键词： 血清CA 卵巢上皮癌 治疗后复发　出处：《中国妇产科临床杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨卵巢上皮癌治疗前后血清CA125变化模式对判断预后和诊断复发的价值。方法采用放射免疫方法对152例卵巢上皮性癌患者治疗前后血清CA125进行连续监测,并采用相关的统计学方法分析卵巢上皮癌治疗前后血清CA125变化模式对判断预后和诊断复发的价值。结果 (1)治疗前血清CA125≤35 U/ml者的PFS和OS高于治疗前血清CA12535 U/ml者(P0.05);治疗后血清CA125呈对数下降者或1个月之内下降至正常者的PFS和OS高于治疗后血清CA125呈非对数下降者或大于1个月下降至正常者(P0.05);(2)多因素Cox回归模型分析显示,治疗前CA125含量(相对危险度量3.274,P=0.025)和治疗后血清CA125含量下降速度(相对危险度量6.213,P=0.002)是患者预后的独立因素;(3)血清CA125诊断卵巢上皮癌复发的ROC曲线下面积为0.879,其诊断敏感性和特异性分别为67.39%和86.79%。结论卵巢上皮癌治疗前后血清CA125变化模式对对判断卵巢上皮性癌预后和诊断复发有重要意义。
[Abstract]:Objective to investigate the value of serum CA125 pattern in predicting prognosis and diagnosing recurrence of ovarian epithelial carcinoma before and after treatment. Methods Serum CA1 in 152 patients with ovarian epithelial carcinoma before and after treatment was studied by radioimmunoassay. 25 continuous monitoring. The changes of serum CA125 in patients with ovarian epithelial carcinoma before and after treatment were analyzed by correlation statistical method. The levels of PFS and OS in patients with serum CA125 鈮，

本文编号：1454345