防粘连膜预防中重度宫腔粘连术后再粘连的疗效分析

发布时间：2018-01-22 10:55

本文关键词： 宫腔粘连防粘连膜几丁糖生长激素　出处：《重庆医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：目的:评价宫内放置防粘连膜(Interceed)在预防中重度宫腔粘连术后再粘连中的疗效。方法:收集2015年6月至2016年6月于郑州大学第二附属医院经宫腔镜检查诊断为中重度宫腔粘连并成功手术分离粘连的72例患者,随机分成2组,A组40例为Interceed组(TCRA宫腔粘连分离术术后宫内放置防粘连膜预防粘连),B组32例为几丁糖组(TCRA宫腔粘连分离术术后宫内灌注医用几丁糖3 m L预防粘连),2组均行TCRA+E2V+生长激素综合治疗。随访术后1个月、3个月2组宫腔再粘连情况及术后3个月子宫内膜生长情况。结果:Interceed组术后1个月总有效率(77.5%)及术后3个月总有效率(87.5%)均明显高于几丁糖组术后1个月总有效率(53.1%)及术后3个月总有效率(56.3%),差异具有统计学意义(P0.05),Interceed组术后3个月内膜生长厚度[(6.38±2.70)mm]明显高于几丁糖组术后3个月内膜生长厚度[(4.97±1.60)mm],差异有统计学意义(P0.05)。结论:Interceed有效预防中重度宫腔粘连术后宫腔再粘连的发生,临床价值高。
[Abstract]:Objective: to evaluate the interceded antiadhesion membrane placed in uterus. The effect of preventing secondary adhesions after moderate and severe intrauterine adhesions. Methods:. From June 2015 to June 2016, 72 patients with moderate and severe intrauterine adhesions were diagnosed by hysteroscopy in the second affiliated Hospital of Zhengzhou University. Group A was randomly divided into two groups: group A (40 cases): Interceed group: intrauterine antiadhesion membrane was placed to prevent adhesion after separation of intrauterine adhesions. Group B (n = 32) was treated with intrauterine intrauterine infusion of chitosan (3ml / L) after intrauterine adhesions separation with TCRA (n = 32). Both groups were treated with TCRA E2V growth hormone and followed up for 1 month. Results the total effective rate of 1 month and 3 months after operation in the two groups was 77.5% and the total effective rate was 77.5 months (P < 0.05) and the total effective rate (3 months after operation) was 77.5% (P < 0.05) and the total effective rate was 77.5% (P < 0.05). The total effective rate was significantly higher in the chitosan group than in the chitosan group at 1 month after operation (53.1%) and in the third month after operation (56.3%). The difference was statistically significant (P 0.05). The thickness of intimal growth was 3 months after operation in the interceed group. [The thickness of intimal growth was significantly higher than that of chitosan group at 3 months after operation. [The difference was statistically significant (P0.050.Conclusion: 1% Interceed is effective in preventing the recurrence of intrauterine adhesions after moderate and severe intrauterine adhesions. The clinical value is high.
【作者单位】：郑州大学第二附属医院妇产科;
【分类号】：R713.4
【正文快照】： 宫腔粘连(intrauterine adhesion,IUA)指各种因素导致子宫内膜基底层受损后,宫腔肌壁和(或)宫颈管的相互粘连,近年发病率呈上升趋势。目前治疗多采用综合疗法,包括宫腔镜下宫腔粘连分离术(trans-cervical resection of adhesions,TCRA),术后口服大剂量戊酸雌二醇(estradiol va

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