卵巢及子宫透明细胞癌、子宫内膜样癌中NapsinA、TTF-1、PAX8及CA125的表达及意义

发布时间：2018-01-25 03:22

本文关键词： 卵巢肿瘤子宫肿瘤透明细胞癌内膜样癌 NapsinA TTF- PAX CA　出处：《临床与实验病理学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的探讨Napsin A、TTF-1、PAX8及CA125在卵巢、子宫内膜透明细胞癌,卵巢和子宫内膜样癌及卵巢浆液性癌中的表达及在诊断及鉴别诊断中的价值。方法选取23例卵巢透明细胞癌、10例卵巢子宫内膜样癌、45例卵巢浆液性癌、11例子宫内膜透明细胞癌、35例子宫内膜样癌,利用免疫组化法评估Napsin A、TTF-1、PAX8及CA125在上述肿瘤中的表达,并复习相关文献。结果 Napsin A在卵巢透明细胞癌及子宫内膜透明细胞癌中的阳性率较高,分别为95.7%(22/23)、72.7%(8/11),在卵巢和子宫内膜样癌中的阳性率较低,分别为10%(1/10)、5.7%(2/35),在卵巢浆液性癌中不表达。Napsin A在卵巢透明细胞癌、卵巢子宫内膜样癌及卵巢浆液性癌中的敏感度差异有统计学意义(P0.01)。在子宫内膜透明细胞癌及子宫内膜样癌中的敏感度差异亦有统计学意义(P0.01)。TTF-1在卵巢透明细胞癌中不表达,在卵巢子宫内膜样癌、浆液性癌、子宫内膜透明细胞癌、子宫内膜样癌中的阳性率分别为30%(3/30)、4.4%(2/45)、9.1%(1/11)、5.7%(2/35)。PAX8在124例肿瘤中均阳性。18.2%(2/11)的子宫内膜透明细胞癌及5.7%(2/35)的子宫内膜样癌中CA125均阴性,其余均阳性。1例子宫内膜透明细胞癌为Napsin A/TTF-1双阳性。所有Napsin A和(或)TTF-1阳性病例均表达PAX8及CA125。结论Napsin A在卵巢透明细胞癌中的阳性率最高,其次为子宫内膜透明细胞癌,在卵巢和子宫子宫内膜样癌中的阳性率较低,在卵巢浆液性癌中不表达。在诊断起源不明的转移性癌时,鉴别诊断时应当把肺腺癌及妇科肿瘤考虑在内,此时联合检测Napsin A、TTF-1及PAX8的表达有助于确诊。
[Abstract]:Objective to investigate the role of Napsin Agna TTF-1, PAX8 and CA125 in clear cell carcinoma of ovary and endometrium. Expression and differential diagnosis of ovarian endometrioid carcinoma and ovarian serous carcinoma. Methods 23 cases of ovarian clear cell carcinoma and 10 cases of ovarian endometrioid carcinoma were selected. 45 cases of ovarian serous carcinoma and 11 cases of endometrial clear cell carcinoma (endometrial clear cell carcinoma) were evaluated by immunohistochemical method for Napsin TTF-1 in 35 cases of endometrial carcinoma. The expression of PAX8 and CA125 in these tumors was reviewed. Results the positive rate of Napsin A was higher in ovarian clear cell carcinoma and endometrial clear cell carcinoma. The positive rate in ovarian and endometrioid carcinoma was 10 / 10 / 10 / 10 / 57 / 35, respectively. Napsin A was not expressed in ovarian clear cell carcinoma. There were significant differences in sensitivity between ovarian endometrial carcinoma and ovarian serous carcinoma (P0.01), and in endometrial clear cell carcinoma and endometrial carcinoma (. P0.01TTF-1 was not expressed in clear cell carcinoma of ovary. The positive rates of ovarian endometrial carcinoma, serous carcinoma, endometrial clear cell carcinoma and endometrial carcinoma were 30 / 3 / 30 / 4 / 4 / 4 / 45 respectively. 9 / 1 / 1 / 11). 5.72% 35% PAX8 positive in 124 cases of endometrial clear cell carcinoma and 5.775% 2 / 35). CA125 was negative in endometrial carcinoma. All other cases were positive for Napsin A / TTF-1. All Napsin A and / or TTF-1 were positive in all cases of endometrial clear cell carcinoma. TTF-1 positive cases all expressed PAX8 and CA125.Conclusion Napsin A has the highest positive rate in ovarian clear cell carcinoma. The second was clear cell carcinoma of endometrium, the positive rate was lower in ovarian and endometrioid carcinoma, but not expressed in ovarian serous carcinoma. Lung adenocarcinoma and gynecologic tumors should be taken into account in differential diagnosis. The expression of TTF-1 and PAX8 in combination with Napsin is helpful for diagnosis.
【作者单位】：浙江省嘉兴市中医医院病理科;
【分类号】：R737.3
【正文快照】： n A;TTF-1;PAX8;CA125卵巢肿瘤是妇科常见的恶性肿瘤之一,约90%的原发恶性卵巢肿瘤为卵巢表面上皮-间质肿瘤,包括浆液性癌、黏液性癌、子宫内膜样癌、透明细胞癌等[1]。正确的组织分型对临床选择治疗方案非常重要。典型的卵巢透明细胞癌诊断不困难,但局灶性透明细胞也可见于卵

【相似文献】