不能确定恶性潜能的子宫平滑肌肿瘤临床病理观察

发布时间：2018-01-25 10:43

本文关键词： 不能确定恶性潜能的平滑肌肿瘤子宫病理预后　出处：《诊断病理学杂志》2008年05期 　论文类型：期刊论文

【摘要】：目的分析子宫不能确定恶性潜能的平滑肌肿瘤(SMTUMP)的临床病理学特征,探讨其诊断及预后。方法报告2例不能确定恶性潜能的子宫平滑肌肿瘤的病理形态学特征以及临床预后,并复习相关文献。结果2例均为绝经后女性,均因子宫肌瘤行切除术,首次手术切除标本考虑为不能确定恶性潜能的子宫平滑肌肿瘤,但2例分别于术后1年和2年复发。复发后再切除的肿瘤,从病理形态上看,1例可以诊断平滑肌肉瘤,1例仍考虑为不能确定恶性潜能的平滑肌瘤。结论绝大多数子宫平滑肌肿瘤可以依据肿瘤的核分裂象多少、是否出现细胞异型以及是否有凝固性肿瘤细胞坏死,区别良、恶性。然而,有一部分病例不具备诊断恶性平滑肌肿瘤的3项指标,但具有较高的复发风险,被命名为不能确定恶性潜能的平滑肌肿瘤。
[Abstract]:Objective to analyze the clinicopathological features of smooth muscle tumor (SMTUMP) which can not determine the malignant potential of uterus. Methods the pathomorphological features and clinical prognosis of 2 cases of uterine smooth muscle tumors with uncertain malignant potential were reported and the related literatures were reviewed. Results 2 cases were postmenopausal women. All patients underwent hysterectomy for leiomyoma. The first surgical specimens were considered as uterine smooth muscle tumors which could not determine the malignant potential, but 2 cases recurred after 1 year and 2 years after operation, and then resected after recurrence. One case of leiomyosarcoma can still be diagnosed as a leiomyoma whose malignant potential can not be determined. Conclusion the majority of uterine smooth muscle tumors can be based on the mitotic image of the tumor. Whether there are abnormal cells and whether there are coagulative tumor cell necrosis, differentiation between benign and malignant. However, some cases do not have three indicators for the diagnosis of malignant smooth muscle tumors, but have a higher risk of recurrence. It is named smooth muscle tumor which can not determine the malignant potential.
【作者单位】：北京大学人民医院病理科;
【分类号】：R737.33
【正文快照】： 子宫平滑肌瘤,在30岁的女性中约占22%~40%,而在子宫恶性间叶肿瘤中,约1/3是平滑肌肉瘤[1]。根据其病理学表现,绝大多数病例可以很明确地区分子宫平滑肌肿瘤的良、恶性。然而,有一部分病例按照通常的诊断标准难以判断其生物学行为,这部分病例无论对于临床医师还是病理医师,都

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