奥硝唑治疗厌氧菌性盆腔感染的临床研究

发布时间：2018-01-25 09:43

本文关键词： 奥硝唑厌氧菌性盆腔感染多中心研究安全性　出处：《中华医院感染学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的探讨奥硝唑治疗厌氧菌引起的盆腔感染临床效果及安全性。方法选取2012年4月-2013年11月厌氧菌性盆腔感染患者160例,随机分为普通组和治疗组,每组各80例,普通组使用替硝唑氯化钠注射液静脉滴注,每次0.5g,每天两次,维持治疗7d,治疗组使用奥硝唑氯化钠注射液静脉滴注,用法同普通组,治疗后对比两组患者治疗效果、细菌清除率及不良反应发生率。结果普通组治愈65例,治愈率81.25%,治疗组治愈66例,治愈率82.50%,两组临床效果相近,差异无统计学意义;细菌清除率普通组为95.35%、治疗组为97.22%,两组临床效果相近,对比差异无统计学意义;治疗后不良反应发生率治疗组为3.75%、普通组为27.50%,两组对比差异有统计学意义(χ2=11.347,P0.05)。结论针对厌氧菌引起的盆腔感染患者使用奥硝唑氯化钠注射液治疗临床效果显著确切,且安全性高,值得临床推广应用。
[Abstract]:Objective to investigate the efficacy and safety of ornidazole in the treatment of pelvic infection caused by anaerobes. Methods 160 patients with anaerobic-induced pelvic infection from April 2012 to November 2013 were selected. The patients were randomly divided into two groups (80 cases in each group). The common group was treated with tinidazole sodium chloride injection (0.5 g, twice a day) for 7 days. The treatment group was treated with ornidazole sodium chloride injection intravenous drip, and compared with the common group after treatment, the treatment effect, bacterial clearance rate and adverse reaction rate were compared between the two groups. Results 65 cases were cured in the common group. The cure rate was 81.25%, 66 cases were cured in the treatment group, and the cure rate was 82.50%. The clinical effect of the two groups was similar, but the difference was not statistically significant. The bacterial clearance rate was 95.35 in the common group and 97.22 in the treatment group. The clinical effect of the two groups was similar, but the difference was not statistically significant. The incidence of adverse reactions after treatment was 3.75 in the treatment group and 27.50 in the common group. The difference between the two groups was statistically significant (蠂 ~ 2 / 11.347). Conclusion Ornidazole sodium chloride injection is effective and safe in the treatment of pelvic infection caused by anaerobes, which is worth popularizing.
【作者单位】：无锡市第九人民医院妇产科;
【基金】：江苏省科技厅基金资助项目(JS20120386)
【分类号】：R711.33
【正文快照】： 盆腔感染性疾病是指女性生殖器官以及周围的结缔组织等部位,发生由于感染等原因而出现的炎症现象,可能有急性、慢性盆腔炎,盆腔、输卵管以及卵巢等部位发生脓肿现象,厌氧菌性盆腔感染不仅对患者的正常生活造成困扰,还对生殖健康造成影响,可能影响生育能力等[1-2]。目前治疗厌

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