宫腔灌注绒毛膜促性腺激素对反复着床失败后冻融胚胎移植妊娠结局的作用

发布时间：2018-01-25 18:34

本文关键词： 体外受精-胚胎移植(IVF-ET) 冻融胚胎移植(FET) 反复种植失败(RIF) 临床妊娠率　出处：《生殖与避孕》2015年02期 　论文类型：期刊论文

【摘要】：目的:探讨胚胎反复着床失败(RIF)后冻融胚胎移植(FET)时行宫腔内灌注基因重组人绒毛膜促性腺激素(rh CG)对妊娠结局的影响。方法:选择既往胚胎RIF再次行FET的208个周期的患者资料进行回顾性分析。将其中FET日宫腔内灌注rh CG为研究组,另按1∶1选择匹配(年龄、既往ET失败次数、不孕类型)对照组。分析比较着床率、自然流产率、生化妊娠率、临床妊娠率、多胎妊娠率。结果:研究组着床率(22.92%)、生化妊娠率(5.77%)、自然流产率(17.78%)均略高于对照组(分别为16.88%、1.92%、16.13%),多胎妊娠率略低于对照组(15.56%vs 19.35%),但差异均无统计学意义(P0.05)。研究组和对照组均未观察到异位妊娠病例,研究组临床妊娠率显著高于对照组(43.27%vs 29.82%),差异有统计学意义(P0.05)。结论:FET日行宫腔内灌注rh CG可以提高RIF患者的临床妊娠率。
[Abstract]:Objective: to investigate the effect of intrauterine perfusion of recombinant human chorionic gonadotropin (rh CGG) on frozen and thawed embryo transfer (FETT) after repeated implantation failure. Methods: the data of 208 cycles of previous embryo RIF undergoing FET were retrospectively analyzed. Intrauterine perfusion of RhCG on FET day was used as the study group. The matched control group was selected according to 1: 1. The rate of implantation, spontaneous abortion, biochemical pregnancy and clinical pregnancy were analyzed and compared. Results: the implantation rate, biochemical pregnancy rate and spontaneous abortion rate in the study group were slightly higher than those in the control group (22.92%, 5.77% and 17.78%, respectively). The pregnancy rate of multiple pregnancies was slightly lower than that of the control group (15.56 vs 19.35). However, there was no significant difference (P 0.05). No ectopic pregnancy cases were observed in the study group and the control group, and the clinical pregnancy rate in the study group was significantly higher than that in the control group (43.27 vs 29.82). Conclusion Intrauterine perfusion of Rh CG on the day of RIF can improve the clinical pregnancy rate of RIF patients.
【作者单位】：广州中山大学孙逸仙纪念医院生殖中心;
【分类号】：R714.8
【正文快照】： 我们猜想,在RIF的患者行冻融胚胎移植(FET)前宫腔内注射h CG是否可以提高患者的妊娠结局。为此,本文通过回顾性分析冻融胚胎移植前行宫腔内注入h CG对妊娠结局的影响,以便为改善RIF患者的治疗结局提供临床依据。1资料与方法1.1研究对象选择2012.04.01~2014.09.25期间在本中心

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