基于倾向值匹配的孕早期感染与子代循环系统先天性畸形的关系

发布时间：2018-01-25 18:14

本文关键词： 孕早期感染循环系统先天性畸形倾向值匹配　出处：《西安交通大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨孕早期感染与子代循环系统先天性畸形的关系。方法在西安市6家三甲医院收集循环系统先天性畸形胎儿/新生儿和正常新生儿共计1 618例,通过问卷调查收集母亲孕期相关信息;采用倾向值匹配的方法,对孕早期未感染组和孕早期感染组进行1∶1匹配后分析。结果对两组间进行倾向值匹配后,所有混杂因素均在两组间达到平衡。匹配后孕早期感染母亲子代发生循环系统先天畸性是孕早期未感染母亲子代的1.65倍(95%CI:1.21~2.24;P=0.001);匹配后孕早期感染母亲子代发生单一循环系统先天畸性是孕早期未感染母亲子代的1.50倍(95%CI:1.02~2.20;P=0.037);匹配后孕早期感染母亲子代发生复杂循环系统先天畸性是孕早期未感染母亲子代的1.90倍(95%CI:1.18~3.06;P=0.008)。结论母亲孕早期感染增加子代循环系统先天性畸形的发生,在孕早期应尽量避免发生感染性疾病,减少子代循环系统先天性心脏病的发生。
[Abstract]:Objective to investigate the relationship between early pregnancy infection and congenital malformation of circulatory system in offspring. Methods 1 618 cases of congenital malformation of circulatory system fetus / newborn and normal newborns were collected in 6 third Class A hospitals of Xi'an. The information about pregnancy was collected by questionnaire survey. Using the method of tendency value matching, 1: 1 matching analysis was carried out on the uninfected group and the early pregnant infected group. Results the tendency value of the two groups was matched. All the confounding factors were balanced between the two groups. The congenital malformation of circulatory system was 1.65 times higher than that of the uninfected maternal offspring in the first trimester. 95 CI: 1.21 2.24; P0. 001; The congenital teratogenicity of single circulatory system was 1.50 times higher than that of uninfected maternal offspring in the first trimester of pregnancy, and 95 CI: 1.02 / 2.20; P0. 037; The congenital teratogenicity of complicated circulatory system was 1.90 times higher than that of the uninfected maternal offspring in the first trimester of pregnancy, and 95 CI: 1.183.06; Conclusion the incidence of congenital malformation of the circulatory system in the offspring should be increased during the early pregnancy, and the incidence of congenital heart disease in the circulatory system of the offspring should be avoided as much as possible in the first trimester of pregnancy.
【作者单位】：西安交通大学公共卫生学院流行病与卫生统计学系;西北妇女儿童医院产科;陕西省人民医院产科;西安交通大学第一附属医院产科;第四军医大学西京医院超声医学科;
【基金】：国家自然科学基金资助项目(No.81230016) 陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013)~~
【分类号】：R714.251
【正文快照】： 先天畸形(出生缺陷)是指胚胎或胎儿在发育过程中发生解剖学和功能上的异常。根据国际疾病分类-10(international classification of diseases,ICD-10)将先天畸形分为神经系统先天性畸形、眼耳面和颈部先天性畸形、循环系统先天性畸形、呼吸系统先天性畸形、唇裂及腭裂、消化系

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