百令胶囊对多囊卵巢综合征代谢指标的影响

发布时间：2018-01-26 00:26

本文关键词： 多囊卵巢综合征百令胶囊达英- 糖代谢尿酸　出处：《首都医科大学学报》2016年04期 　论文类型：期刊论文

【摘要】：目的观察百令胶囊辅助治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)的疗效,研究其对糖脂代谢和肝肾功能的影响。方法将90例PCOS患者采用随机数字表法随机分为研究组(50例)和对照组(40例)。研究组采用达英-35联合百令胶囊,对照组单用达英-35,观察并比较两组治疗3个月前后空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素[fasting insulin,INS(OH)]、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoproteincholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、载脂蛋白AI(apolipoprotein AI,Apo AI)、载脂蛋白B(apolipoprotein B,Apo B)、脂蛋白a[lipoprotein a,Lp(a)]、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、r-谷氨酰转移酶(gamma-glutamyl transpeptidase,GGT)、血肌酐(creatinine,Cr)、尿素氮(blood urea nitrogen,BUN)、尿酸(uric acid,UA)等一系列代谢指标的变化。结果 1治疗后两组TC均升高(P0.05),HDL-C轻度升高(P0.05);研究组TG浓度较对照组低(P0.05);研究组治疗前后LDL-C差异无统计学意义,对照组显著下降(P0.05);治疗后两组Apo AI、Apo B均升高,Lp(a)降低(P0.05),组间比较差异无统计学意义(P0.05)。2研究组FPG、胰岛素抵抗较前降低(P0.05),空腹胰岛素轻度降低(P0.05);研究组上述指标均较对照组低(P0.05)。3与治疗前相比,研究组Cr和BUN差异无统计学意义(P0.05),UA降低(P0.05),对照组上述指标治疗前后差异无统计学意义(P0.05);治疗后研究组UA较对照组明显降低,其余指标组间比较差异无统计学意义。4肝功能指标在组内和组间比较差异无统计学意义。结论达英-35联合百令胶囊治疗PCOS患者能够改善糖代谢和胰岛素抵抗,对脂代谢有良好作用,保护肾功能,且对肝功能无不良影响。因此,百令胶囊能够作为治疗PCOS的辅助用药。
[Abstract]:Objective to observe the efficacy of bailing capsule in the treatment of polycystic ovary syndrome (PCOS). Methods 90 patients with PCOS were randomly divided into study group (n = 50) and control group (n = 40). The study group was treated with dain-35 combined with bailing capsule. The control group was treated with dain-35 alone. The fasting plasma glucose and fasting insulin were observed and compared between the two groups before and after 3 months of treatment. [Total cholesterol (TC), total cholesterol (TC), triglyceride (triglyceride, triglyceride, triglyceride, triglyceride, triglyceride, triglyceride, triglyceride, triglyceride, triglyceride). High density lipoprotein cholesterol (HDL-C). Low density lipoprotein-cholesterol (LDL-C). Apolipoprotein AI(apolipoprotein, apolipoprotein, apolipoprotein, apolipoprotein, apolipoprotein, apolipoprotein, apolipoprotein, apolipoprotein, apolipoprotein A. [Lipoprotein, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase, alanine aminotransferase (alt). Aspartate aminotransferase (AST). R-glutamyl transpeptidase (GGTN), creatinine creatinine (Cr). Urea nitrogen blood urea nitrogenin bun, uric acid uric acid. Results (1) after treatment, TC in both groups increased P0.05 and HDL-C increased slightly. The concentration of TG in the study group was lower than that in the control group (P 0.05). There was no significant difference in LDL-C before and after treatment in the study group, while in the control group it decreased significantly (P 0.05). After treatment, the Apo of the two groups increased significantly (P 0.05), and the FPG of the study group was not significantly different (P 0.05). Compared with the former, insulin resistance decreased P0.05A, fasting insulin decreased slightly (P0.05N). The above indexes in the study group were lower than those in the control group (P 0.053.Compared with those before treatment, there was no significant difference in Cr and BUN between the study group and the control group. In the control group, there was no significant difference between the above indexes before and after treatment (P 0.05). After treatment, UA in the study group was significantly lower than that in the control group. There was no significant difference in the other indexes between groups. 4. There was no significant difference in liver function between groups and within groups. Conclusion Dain-35 combined with Bering capsule can improve glucose metabolism and pancreas metabolism in patients with PCOS. Island resistance. It has good effect on lipid metabolism, protects renal function, and has no adverse effect on liver function. Therefore, bailing capsule can be used as an adjuvant drug in the treatment of PCOS.
【作者单位】：首都医科大学附属北京妇产医院内分泌科;德国图宾根大学妇产医院绝经内分泌中心;
【基金】：北京市自然科学基金(Y161011) 北京市卫生系统高层次卫生技术人才(2014-2-016) 国家外国专家局2016年度北京市引进国外技术、管理人才项目(高外端)(20161100031) 首都医科大学附属北京妇产医院,北京妇幼保健院学科带头人项目(2013-1)~~
【分类号】：R711.75
【正文快照】： 多囊卵巢综合征(polycystic ovary syndrome,P-COS)是育龄期妇女最常见的内分泌及代谢紊乱性疾病之一。PCOS表现具有高度异质性,如月经稀发或无排卵、多毛、痤疮等,远期合并症包括肥胖、2型糖尿病、代谢综合征、心血管疾病等。多项研究[1-2]显示PCOS患者发生上述远期合并症的

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