外周血循环miRNA诊断卵巢癌的Meta分析

发布时间：2018-01-26 00:58

本文关键词： 卵巢肿瘤/诊断微RNAs/血液 Meta分析(主题)　出处：《实用肿瘤杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的综合评价外周血循环微小RNA(microRNA,miRNA)对卵巢癌的诊断价值。方法全面检索Pub Med、The Cochrane Library、ISI Web of Science、CNKI、万方和维普数据库,按照纳入与排除标准收集从各数据库建库至2015年5月发表的关于运用外周血循环miRNA表达水平诊断卵巢癌的文献,应用Meta-Di Sc 1.4软件进行Meta分析。结果共9项关于外周血循环miRNA诊断卵巢癌的研究纳入本次分析,共1 068例研究对象。Meta分析结果显示,外周血循环miRNA诊断卵巢癌的合并敏感度和合并特异性分别为0.74(95%CI:0.71~0.78)和0.76(95%CI:0.72~0.80),合并诊断阳性似然比和阴性似然比分别为3.03(95%CI:2.17~4.21)和0.32(95%CI:0.25~0.43),合并诊断比值比为10.70(95%CI:6.82~16.78)。总受试者工作特征曲线下面积为0.83,Q*值为0.77。结论外周血循环miRNA对卵巢癌具有一定的诊断价值。
[Abstract]:Objective to evaluate the diagnostic value of microRNA-miRNAs in peripheral blood circulation for ovarian cancer. Methods Pub Med was searched comprehensively. The Cochrane Library ISI Web of Science CNKI, Wanfang and Weip databases. According to the inclusion and exclusion criteria collected from the establishment of databases to May 2015 published on the use of peripheral blood circulation miRNA expression level of diagnosis of ovarian cancer literature. Meta-Di Sc1.4 software was used for Meta analysis. Results 9 studies on peripheral blood circulation miRNA diagnosis of ovarian cancer were included in this analysis. A total of 1 068 cases were studied. Meta-analysis showed that. The combined sensitivity and specificity of peripheral circulating miRNA in the diagnosis of ovarian cancer were 0.74, 95 CI: 0.71 and 0.76, respectively. 95 CI: 0.72 0.80). The positive likelihood ratio and negative likelihood ratio of combined diagnosis were 3.03 ~ 95CI: 2.17 ~ 4.21) and 0.32 ~ 95% CI: 0.25 ~ (0.43) respectively. The ratio of combined diagnosis was 10.70% 95% CI: 6.82% 16.780.The area under the operating characteristic curve of the total subjects was 0.83. The Q * value is 0.77. Conclusion miRNA in peripheral blood circulation is valuable in the diagnosis of ovarian cancer.
【作者单位】：南京市妇幼保健院检验科;
【分类号】：R737.31
【正文快照】： 卵巢癌是女性常见的三大生殖器官恶性肿瘤之一,病死率占妇科恶性肿瘤首位,严重威胁着广大妇女的生命健康。由于缺乏特异性的临床表现和有效的早期诊断方法,70%~80%的患者就诊时已是晚期,常伴有腹部和骨盆转移。晚期卵巢癌患者5年生存率仅20%~30%,而早期卵巢癌患者5年生存率则

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