过敏体质与女童反复外阴阴道炎的相关性研究

发布时间：2018-01-28 03:48

本文关键词： 过敏反复外阴阴道炎免疫球蛋白E 女童　出处：《东南大学学报(医学版)》2015年05期 　论文类型：期刊论文

【摘要】：目的:通过分析女童病因不明的反复外阴阴道炎(RVV)过敏原特点、过敏家族史和过敏相关疾病的关系,探讨女童RVV的发生与过敏的相关性。方法:采用前瞻性病例对照研究,选择病因不明的200例青春期前RVV患者为观察组,同期参加健康查体、年龄相仿的200例健康女童为对照组,两组均行过敏原血清特异性IgE测定,记录过敏相关疾病及家族史。结果:观察组过敏原阳性率以及过敏家族史、吸入过敏、食物过敏的阳性率均明显高于对照组(P0.001)。观察组中有过敏家族史者sIgE阳性组远高于sIgE阴性组(P0.001),合并湿疹、鼻炎、哮喘等过敏性疾病者阳性组远高于阴性组(P0.001)。结论:女童RVV与过敏体质有关,虽然这种关系的确切机制还有待研究,但过敏体质可能是RVV致病和(或)发病的促进因素。
[Abstract]:Objective: to analyze the relationship between allergen, family history of allergies and allergy related diseases in girls with recurrent vulvovaginitis with unknown etiology. Methods: a prospective case-control study was conducted to investigate the correlation between RVV and allergies in girls. 200 patients with prepubertal RVV with unknown etiology were selected as observation group and health check-up was conducted at the same time. Two hundred healthy girls of similar age served as the control group. The allergen serum specific IgE was measured in both groups and the allergen-related diseases and family history were recorded. Results: the positive rate of allergen and the family history of allergen were recorded in the observation group. The positive rate of food allergy in inhaled allergy group was significantly higher than that in control group (P 0.001). The sIgE positive group with family history of allergy was much higher than sIgE negative group (P 0.001). Patients with allergic diseases such as eczema, rhinitis, asthma were significantly higher in positive group than in negative group P0.001.Conclusion: RVV in girls is related to allergic constitution, although the exact mechanism of this relationship remains to be studied. However, allergic constitution may be a contributing factor to the pathogenesis and / or pathogenesis of RVV.
【作者单位】：中山市妇幼保健院儿科;
【基金】：中山市科技局立项项目(2014A1FC019)
【分类号】：R711.31
【正文快照】： 近年来人们认识到,女童可以发生如成年妇女一样的妇科疾病,其中外阴阴道炎是女童最常见的妇科问题[1-2]。引起外阴阴道炎病因很多,感染是最常见的,但反复外阴阴道炎(recurrent vulvovaginitis ofundetermined etiology,RVV)的病因分析目前仍在研究当中。我院曾报道705例RVV患

【参考文献】