术后化疗在IA2-IB1期单纯低分化宫颈鳞癌患者预后研究

发布时间：2018-01-28 04:37

本文关键词： 低分化宫颈鳞癌化疗　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨术后辅助化疗对IA2-IB1期单纯低分化宫颈鳞癌患者预后的影响。方法:采用回顾性分析方法,收集2003年2月~2014年2月就诊于广西医科大学第一附属医院妇科的76例IA2-IB1期单纯低分化高危因素宫颈鳞癌手术患者的病例资料,根据术后辅助化疗情况,分为观察组(手术+术后化疗组42例)和对照组(单纯手术组34例),对比两组患者预后生存指标,并总结观察组患者的化疗毒副反应。结果:所有患者累计总生存率、无复发生存率、无远处转移生存率及无局部复发生存率分别为93.9%、94.7%、96.1%、98.7%,其中观察组患者总生存率、无复发生存率均优于对照组(P0.05),且远处转移率(0%)低于对照组(8.8%),而无局部复发生存率两组患者比较差异无显著性(P0.05)。观察组所有患者均完成了所有疗程化疗,化疗毒副反应主要为胃肠道反应23.81%(10/42),骨髓抑制19.04%(8/42),周围神经障碍14.29%(6/42),肝肾功能损害4.76%(2/42),均为可逆性。结论:针对单纯低分化高危因素的IA2-IB1期宫颈鳞癌患者,术后辅助化疗不仅提高患者总生存率,还降低复发率,且化疗不良反应的可逆性在提高患者的生活质量中具有一定优势,是一种可行的治疗选择。
[Abstract]:Objective: to investigate the effect of postoperative adjuvant chemotherapy on prognosis of patients with simple poorly differentiated squamous cell carcinoma of the cervix (IA2-IB1). From February 2003 to February 2014, 76 cases of cervical squamous cell carcinoma (SCC) with low differentiation and high risk factors were collected from gynecological department of the first affiliated Hospital of Guangxi Medical University. According to the postoperative adjuvant chemotherapy, the patients were divided into observation group (42 cases of postoperative chemotherapy group) and control group (34 cases of simple operation group). Results: the cumulative overall survival rate, recurrence free survival rate, distant metastasis free survival rate and local recurrence free survival rate of all patients were 93.9% or 94.7% respectively. The overall survival rate and recurrence free survival rate of the patients in the observation group were better than those in the control group (P 0.05), and the distant metastasis rate was lower than that in the control group (P < 0.01). However, there was no significant difference between the two groups in the survival rate of no local recurrence (P 0.05). All the patients in the observation group completed all the courses of chemotherapy. The side effects of chemotherapy were mainly gastrointestinal reaction 23.81% 10 / 42, bone marrow suppression 19.0410 / 42, peripheral nerve disturbance 14.29 / 42). Liver and kidney function damage 4.76 / 42%, are reversible. Conclusion: simple low differentiation risk factors for IA2-IB1 patients with cervical squamous cell carcinoma. Postoperative adjuvant chemotherapy not only improves the overall survival rate, but also reduces the recurrence rate. The reversibility of adverse reactions of chemotherapy has some advantages in improving the quality of life of patients, and it is a feasible treatment choice.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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