阴道微生态与高危型人乳头瘤病毒感染对老年宫颈病变患者的影响及其关系

发布时间：2018-01-28 20:02

本文关键词： 宫颈病变阴道微生态高危型人乳头瘤病毒危险因素　出处：《中国老年学杂志》2017年23期 　论文类型：期刊论文

【摘要】：目的探讨阴道微生态与高危型人乳头瘤病毒(HPV)感染对老年宫颈病变患者的影响及其相关性。方法选取老年宫颈病变患者100例作为宫颈病变组,另取同期体检无宫颈病变健康老年人100例作为宫颈正常组。检测两组阴道微生态情况,同时检测高危型HPV感染情况,采用Logistic逐步回归方法分析两者相关性。结果宫颈病变组乳酸杆菌阳性人数占比显著低于宫颈正常组,阴道清洁度3~4级、念珠菌阳性人数占比均显著高于宫颈正常组(均P0.05)。宫颈病变组高危型HPV感染阳性率显著高于对照组(P0.05)。经多因素Logistic回归分析发现,乳酸杆菌、阴道清洁度、念珠菌及高危型HPV感染均为影响宫颈病变的独立危险因素(P0.05)。结论老年宫颈病变患者具有明显的阴道微生态失调情况,乳酸杆菌、阴道清洁度、念珠菌及高危型HPV感染均为影响宫颈病变的独立危险因素。
[Abstract]:Objective to investigate the effect of vaginal microecology and high risk HPV infection on elderly patients with cervical lesions. Methods 100 cases of cervical lesions were selected as cervical lesions group. In addition, 100 healthy elderly people without cervical lesion were selected as normal cervical group. The vaginal microecology and high-risk HPV infection were detected in both groups. Results the positive rate of Lactobacillus in cervical lesion group was significantly lower than that in normal cervix group, and vaginal cleanliness was 3 ~ 4 grade. The positive rate of positive rate of Candida was significantly higher than that of normal cervix (P 0.05). The positive rate of high-risk HPV infection in cervical lesion group was significantly higher than that in control group (P 0.05). By multivariate Logistic regression analysis. Lactobacillus, vaginal cleanliness. Candida candida and high risk HPV infection are independent risk factors for cervical lesions P0.05.Conclusion elderly patients with cervical lesions have obvious vaginal microecological disorders Lactobacillus. Vaginal cleanliness, Candida and high-risk HPV infection were independent risk factors for cervical lesions.
【作者单位】：连云港市第一人民医院妇产科;常州市第一人民医院妇产科;连云港市第一人民医院检验科;南京鼓楼医院妇产科;
【分类号】：R737.33
【正文快照】： 人乳头瘤病毒(HPV)感染可能是引发生殖道肿瘤的致病因素之一[1],且HPV感染是导致宫颈病变发生的必要条件。生殖道感染的HPV亚型达30多种,主要分为高危型和低危型,其中高危型HPV持续感染更是导致宫颈病变发生的必要条件[2]。以往认为HPV感染多发于性生活活跃的中青年女性,然而

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