早发型和晚发型重度子痫前期的异常补体激活

发布时间：2018-01-28 19:28

本文关键词： 早发型重度子痫前期晚发型重度子痫前期补体系统异常激活　出处：《中国妇产科临床杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的探讨早发型和晚发型重度子痫前期中的补体经典和旁路途径异常激活。方法选取2013年7月-2014年11月在北京大学第一医院妇产科住院分娩的早发型重度子痫前期(severe preeclampsia,sPE)患者30例(早发sPE组)和晚发型重度子痫前期患者30例(晚发sPE组)为研究组,孕周匹配的正常妊娠孕妇为早、晚发型重度子痫前期的对照组(各30例)。采用酶联免疫法(ELISA)检测孕妇血浆补体C1q、C4d、C3a、Bb及膜攻击复合物(MAC)水平。结果 1晚发sPE组C1q、C4d、C3a和MAC水平分别为118.25μg/ml(84.78~161.00μg/ml)、10.77μg/ml(3.66~22.32μg/ml)、4 018.80μg/ml(948.98~10 406.13μg/ml)和293.94ng/ml(205.45~351.38ng/ml);晚发对照组各补体水平分别为92.06μg/ml(78.33~107.73μg/ml)、5.12μg/ml(2.80~9.34μg/ml)、34.80μg/ml(26.41~53.02μg/ml)和119.59ng/ml(50.97~200.09ng/ml)。两组各指标比较,差异有统计学意义(P均0.05)。2早发sPE组Bb、C3a和MAC水平分别为0.70μg/ml(0.57~0.77μg/ml)、872.66μg/ml(223.83~8 837.00μg/ml)和325.56ng/ml(231.95~442.23ng/ml);早发对照组各补体水平分别为0.41μg/ml(0.40~0.50μg/ml)、38.63μg/ml(28.98~48.85μg/ml)和101.75ng/ml(97.86~140.48ng/ml)。两组各指标比较,差异有统计学意义(P均0.05)。结论补体系统异常激活与重度子痫前期发病有关,其中补体经典途径可能更多参与晚发型重度子痫前期的发病,早发型重度子痫前期的发病可能与补体旁路途径的激活有关。
[Abstract]:Objective to investigate the abnormal activation of complement classic and bypass pathway in early onset and late onset severe preeclampsia. Methods: from July 2013 to November 2014 in the first Hospital of Peking University in the Department of Gynecology and Obstetrics and Obstetrics and Obstetrics and Obstetrics. Early onset of severe preeclampsia (. Severe preeclampsia. Thirty patients (early onset sPE group) and 30 patients with late onset severe preeclampsia (late onset sPE group) were treated as study group. Normal pregnant women with matched gestational weeks were early pregnant women. In the control group (30 cases each) of late onset severe preeclampsia (30 cases each), the plasma complement C1qC4dC3a of pregnant women was detected by enzyme-linked immunosorbent assay (Elisa). Results\\\ the level of BB and membrane attack complex was 4 d in sPE group. The levels of C3a and MAC were 118.25 渭 g / ml, 84.78 渭 g / ml and 161.00 渭 g / ml, respectively. 10.77 渭 g / ml 3.66 渭 g / ml 22.32 渭 g / ml). 4018.80 渭 g / ml 948.98 渭 g / ml 10 406.13 渭 g / ml) and 293.94 ng / ml / ml 205.45 渭 g / ml / ml 351.38 ng / ml / ml; The complement levels of the late onset control group were 92.06 渭 g / ml 78.33 渭 g / ml 107.73 渭 g / ml / ml 5.12 渭 g / ml / ml 2.80 渭 g / ml 2.80 渭 g / ml / ml 9.34 渭 g / ml respectively. 34.80 渭 g / ml 26.41 渭 g / ml, 53.02 渭 g / ml) and 119.59 ng / ml 50.97 ng / ml / ml, 200.09 ng / ml, respectively. The difference was statistically significant (P < 0.05). The levels of BbC3a and MAC were 0.70 渭 g / ml, 0.57 渭 g / ml and 0.77 渭 g / ml in early onset sPE group, respectively. 872.66 渭 g / ml 223.83 渭 g / ml (8 837.00 渭 g / ml) and 325.56 ng / ml 231.95 ng / ml ~ 442.23 ng / ml / ml; The complement levels of early onset control group were 0.41 渭 g / ml 0.40 渭 g / ml 0.50 渭 g / ml respectively. 38.63 渭 g / ml 28.98 渭 g / ml (48.85 渭 g / ml) and 101.75 ng / ml / ml 97.86 ~ 140.48 ng / ml ~ (-1). Conclusion abnormal activation of complement system is related to the onset of severe preeclampsia, in which the classical pathway of complement may be more involved in the pathogenesis of late onset severe preeclampsia. Early onset of severe preeclampsia may be associated with activation of the complement bypass pathway.
【作者单位】：北京大学第一医院妇产科;
【分类号】：R714.244
【正文快照】： Chin J Clin Obstet Gynecol,2015,16:119-122子痫前期(preeclampsia,PE)是妊娠特发性疾病,是孕产妇和新生儿患病率和死亡率升高的主要原因。目前关于子痫前期发病机制的研究主要有以下几个方面:滋养细胞浸润能力异常[1],免疫调节功能异常[2],遗传因素[3],氧化应激反应[4],饮

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