DENND1A基因多态性与多囊卵巢综合征易感性的Meta分析

发布时间：2018-01-29 19:22

本文关键词： DENNDA基因多囊卵巢综合征基因多态性 Meta分析　出处：《南京医科大学学报(自然科学版)》2017年10期 　论文类型：期刊论文

【摘要】：目的:探讨DENND1A基因多态性与多囊卵巢综合征(polycystic ovary syndrome,PCOS)发病的相关性。方法:检索Pub Med、EMBASE等数据库得到DENND1A基因多态性与PCOS相关性的研究,计算相关基因位点的OR值和95%可信区间(95%CI)。结果:本研究共纳入8篇DENND1A基因多态性的文献,总体人群中rs10818854、rs2479106、rs10986105与PCOS的发病存在相关性;亚组分析表明:亚洲人种中rs10818854、rs10986105的各遗传模型及rs2479106除隐性模型外的遗传模型其合并OR值(95%CI)均大于1.00(P0.05);在欧美人种中rs10818854、rs10986105除隐性模型及加性模型外的3种遗传模型其合并OR值(95%CI)均大于1.00(P0.05);而rs2479106与PCOS的发病无关(P0.05)。结论:DENND1A基因多态性与PCOS的发生相关,但存在种族差异,在亚洲人种中rs10818854、rs2479106、rs10986105与PCOS的发病相关,在欧美人种中rs10818854、rs10986105与PCOS的发病相关,rs2479106与PCOS的发病无关联。
[Abstract]:Objective: to investigate the relationship between DENND1A gene polymorphism and polycystic ovary syndrome (PCOS). Methods: the association between DENND1A gene polymorphism and PCOS was obtained by searching Pub Medus EMBASE database. OR value and 95% confidence interval (CI) were calculated. Results: eight articles of DENND1A gene polymorphism were included in this study. Rs10818854 rs2479106 and rs10986105 were correlated with the incidence of PCOS. Subgroup analysis showed that rs10818854 was found in Asian race. The genetic model of rs10986105 and the genetic model of rs2479106 except recessive model were all larger than 1.00 P0.05. Rs10818854 in European and American species. All the three genetic models of rs10986105 except recessive model and additive model were greater than 1.00 P0.05. However, rs2479106 was not associated with the pathogenesis of PCOS (P0.05A). Conclusion\\\% DENND1A gene polymorphism is associated with the occurrence of PCOS, but there are ethnic differences. Rs10818854 rs2479106 / rs10986105 was associated with the onset of PCOS, and rs10818854 was found in European and American populations. There was no correlation between rs10986105 and PCOS, rs2479106 and PCOS.
【作者单位】：东南大学附属中大医院妇产科;东南大学医学院;
【分类号】：R711.75
【正文快照】： 多囊卵巢综合征(polycystic ovary syndrome,PCOS)是以稀发排卵或无排卵、高雄激素、多囊卵巢为特征的内分泌紊乱症候群。根据近年来的抽样调查发现我国发病率在5%~10%[1-3]。稀发排卵及内分泌紊乱是导致女性不孕症的主要原因之一,严重危害女性的身心健康。而其核心发病机制—

【相似文献】