不同绝经阶段女性脱氢表雄酮和雌二醇及血清睾酮的表达及与脂糖代谢的关系

发布时间：2018-01-29 20:26

本文关键词： 绝经脱氢表雄酮雌二醇血清睾酮脂糖代谢　出处：《中国老年学杂志》2015年17期 　论文类型：期刊论文

【摘要】：目的探讨不同绝经期阶段女性脱氢表雄酮(DHEA)、雌二醇(E2)、血清睾酮(T)的表达及与脂糖代谢的关系。方法抽取该院妇产科2012年6月至2014年1月常规体检妇女150例,根据是否绝经及绝经时间分为对照组30例、观察A组35例、观察B组29例、观察C组27例、观察D组29例,检测研究对象DHEA、E2、T以及脂糖代谢指标,分析其表达与脂糖代谢的关系。结果五组间DHEA、E2、T水平具有统计学差异(P0.05)。甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹胰岛素(FIN)在五组间无统计学差异(P0.05),而总胆固醇(TC)和空腹血糖(FBG)在五组间差异显著(P0.05)。DHEA与TC、TG、LDL-C、FBG呈负相关(P0.05);E2与TC、LDL-C、FBG呈正相关(P0.05);T与TC、HDL-C呈负相关(P0.05)。结论女性绝经后产生了胰岛素抵抗,DHEA、E2、T与脂糖指标呈协同或者拮抗关系。
[Abstract]:Objective to study the dehydroepiandrosterone (DHEAA) and estradiol (E2) in women at different menopausal stages. The expression of serum testosterone (T) and its relationship with lipid and glucose metabolism. Methods 150 women with routine physical examination from June 2012 to January 2014 were selected from the department of gynecology and obstetrics of our hospital from June 2012 to January 2014. According to the time of menopause and menopause, 30 cases were divided into control group (n = 30), group A (n = 35), group B (n = 29), group C (n = 27) and group D (n = 29). Results there was a statistical difference in the levels of DHEAA E2N T between the five groups (P 0.05) and triglyceride triglyceride (TG). Low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting insulin (fins) were not significantly different among the five groups (P 0.05). There were significant differences in total cholesterol (TC) and fasting blood glucose (FBG) among the five groups (P 0.05). DHEA was negatively correlated with TGG LDL-C0. 05 FBG. There was a positive correlation between E _ 2 and TCU LDL-C FBG (P 0.05). Conclusion there is a synergistic or antagonistic relationship between insulin resistance (DHEAE _ 2T) and lipid sugar index in postmenopausal women.
【作者单位】：长治医学院附属和平医院生殖遗传科;长治医学院附属和平医院产科;长治医学院附属和平医院妇科;
【分类号】：R711.75
【正文快照】： 绝经后女性生理指标均发生变化,雌激素水平下降,雄激素水平上升,同样脂糖代谢紊乱发病率呈现上升趋势〔1〕。临床研究发现雄激素与脂糖代谢紊乱可能具有相关关系,同样发现围绝经期女性睾酮、雌激素以及雄激素水平较高,绝经期发生代谢综合征危险性较高〔2〕。本文拟分析不同绝

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